典型文献
Perspectives on the flexibility analysis for continuous pharmaceutical manufacturing processes
文献摘要：
Pharmaceutical continuous manufacturing,especially under the context of COVID-19 pandemic,is regarded as an emerging technology that can guarantee the adequate quality assurance and mitigate pro-cess risk while guaranteeing the desirable economic performance.Flexibility analysis is one approach to quantitively assess the capability of chemical process to guarantee feasible operation in face of variations on uncertain parameters.The aim of this paper is to provide the perspectives on the flexibility analysis for continuous pharmaceutical manufacturing processes.State-of-the-art and progress in the flexibility anal-ysis for chemical processes including concept evolution,mathematical model formulations,solution strategies,and applications are systematically overviewed.Recent achievements on the flexibility/feasi-bility analysis of the downstream dosage form manufacturing process are also touched upon.Further challenges and developments in the field of flexibility analysis for novel continuous manufacturing pro-cesses of active pharmaceutical ingredients along with the integrated continuous manufacturing pro-cesses are identified.
文献关键词：
中图分类号：
作者姓名：
Wenhui Yang;Wuxi Qian;Zhihong Yuan;Bingzhen Chen
作者机构：
State Key Laboratory of Chemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China;Department of Chemical Engineering,Tsinghua University,Beijing 100084,China
文献出处：
引用格式：
[1]Wenhui Yang;Wuxi Qian;Zhihong Yuan;Bingzhen Chen-.Perspectives on the flexibility analysis for continuous pharmaceutical manufacturing processes)[J].中国化学工程学报（英文版）,2022(01):29-41
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0.55576
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