Objective:To demonstrate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the ipsilesional dorsolateral prefrontal cortex (DLPFC) on neurological recovery in patients with subacute phase stroke.Methods:Patients with supratentorial hemispheric stroke who were hospitalized for intensive rehabilitation in the subacute phase were enrolled for this retrospective analysis. Two groups of patients were selected: the rTMS group who received high-frequency (20 Hz) rTMS ≥ 5 times over the ipsilesional DLPFC, and a control group who did not receive any rTMS. The patients were further divided into groups with right- or left-side brain lesions. Functional measurements for cognitive ability, mood, speech, and activities of daily living, which were assessed at baseline and at the 1-month follow-up as a routine clinical practice, were used for analyses.Results:Among 270 patients with available clinical data, 133 (women, 51; age, 61.0±13.8 years) met the inclusion criteria and were enrolled for analysis. There were no differences in demographic data and functional scores at baseline between the rTMS ( n＝49) and control ( n＝84) groups. The rTMS group showed a higher gain in the mini-mental status examination (MMSE) total score and subscores of all domains, forward digit span, and FIM-cognition than the control group ( P<0.05). Among the patients with left hemispheric lesions ( n＝57), the rTMS group showed better outcomes in cognition and depression through scores of total and " attention and concentration" subscores of MMSE, FIM-cognition, and the geriatric depression scale ( P<0.05). Among the patients with right hemispheric lesions ( n＝76), the rTMS group showed better outcomes in cognition through the MMSE total score and subscores of " attention and concentration，" " registration，" and " recall，" and scores of both forward and backward digit spans ( P<0.05)． Conclusions:High-frequency rTMS over the ipsilesional DLPFC has beneficial effects on the recovery of cognition on both sides as well as mood in patients with left-sided hemispheric lesions.

中华物理医学与康复杂志

[1]-.Effect of cognition recovery by repetitive transcranial magnetic stimulation on ipsilesional dorsolateral prefrontal cortex in subacute stroke patients)[J].中华物理医学与康复杂志,2022(10):927

ipsilesional,subscores

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