Objective:To observe the efficacy and safety of Guihuang Formula(GHF)in treating patients with type Ⅲ prostatitis and Chinese medicine syndrome of dampness-heat and blood stasis.Methods:Sixty-six type Ⅲprostatitis patients with dampness-heat and blood stasis syndrome were randomly divided into the treatment group(GHF)and the control group(tamsulosin)using a random number table,with 33 cases each group.The treatment group received GHF twice a day,and the control group received tamsulosin 0.2 mg once daily before bedtime.Patients in both groups received treatment for 6 weeks and was followed up for 2 weeks.The outcomes included the National Institute of Health Chronic Prostatitis Symptom Index(NIH-CPSI)score,Chinese Medicine Symptoms Score(CMSS),expressed prostatic secretions(EPS)and adverse events(AEs).Results:After treatment,the NIH-CPSI total score and domain scores of pain discomfort,urination and quality of life decreased significantly from the baseline in both groups(P＜0.05).The CMSS score decreased in both groups(P＜0.05).The white blood cell(WBC)count decreased and lecithin body count increased in both groups(P＜0.05).GHF showed a more obvious advantage in reducing the pain discomfort and quality of life domain scores of NIH-CPSI,reducing the CMSS score,increasing the improvement rate of the WBC and lecithin body counts,compared with the control group(P＜0.05).There were no significant differences in decreasing urination domain score of NIH-CPSI between two groups(P＞0.05).In addition,no serious AEs were observed.Conclusion:GHF is effective in treating type Ⅲ prostatitis patients with dampness-heat and blood stasis syndrome without serious AEs.(Registration No.ChiCTR1900026966)

LIU Sheng-jing;DENG Ying-jun;ZENG Yin;ZHAO Ming;GUO Jun;GAO Qing-he

Department of Andrology,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China;Graduate School of China Academy of Chinese Medical Sciences,Beijing 100700,China;Department of Andrology,Beijing Chinese Medicine Hospital Affiliated to Capital Medical University,Beijing 100010,China;Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China

中国结合医学杂志（英文版）

[1]LIU Sheng-jing;DENG Ying-jun;ZENG Yin;ZHAO Ming;GUO Jun;GAO Qing-he-.Efficacy and Safety of Guihuang Formula in Treating Type Ⅲ Prostatitis Patients with Dampness-Heat and Blood Stasis Syndrome:A Randomized Controlled Trial)[J].中国结合医学杂志（英文版）,2022(10):879-884

Guihuang,Dampness,Stasis,GHF,tamsulosin,bedtime,ChiCTR1900026966

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