典型文献
Effectiveness of redcore lotion in patients with vulvovaginal candidiasis:a systematic review and Meta-analysis
文献摘要：
OBJECTIVE:To summarize and evaluate the effectiveness and safety of Redcore lotion on treating vulvovaginal candidiasis(VVC)using a systematic review and Meta-analysis of randomized controlled trials.METHODS:A systematic literature search was performed in five English and three Chinese electronic databases up to October 2019.Randomized controlled trials in the treatment for VVC were included;only studies which compared the effectiveness and safety of Redcore lotion plus miconazole with miconazole alone were included.Relative risk(RR)and 95％confidence intervals(CI)were used in the Meta-analysis.RESULTS:Seven studies involving 768 patients suffering from WC were identified;468 of the patients were pregnant women(60.9％).Combination group(Redcore lotion plus miconazole)was more effective in reduC/ng symptomatic episodes of WC than miconazole alone,with respect to cure rate(RR,1.31;95％CI,1.09-1.57;P=0.01),fungal culture negative rate(RR,1.21;95％C/,1.04-1.41;P=0.01),and effective rate(RR,1.18;95％CI,1.05-1.35;P=0.01).Subgroup analyses for pregnant women also showed that the combination group had superior outcomes with respect to WC cure rate(RR,1.48;95％CI,1.16-1.88,P＜0.01),fungal culture negative rate(RR,1.26;95％CI;1.09-1.47;P＜0.01),and effective rate(RR,1.25;95％CI,1.10-1.42;P＜0.01).Additionally,the observed risk of adverse events was lower in the combination medication group(RR,0.30;95％CI,0.14-0.65;P＜0.01).CONCLUSIONS:Though overall quality of individual studies was low,Redcore lotion plus miconazole can significantly improve clinical effectiveness and safety compared with miconazole alone.
文献关键词：
中图分类号：
作者姓名：
DING Lijuan;YIN Lu;WANG Liping;SUN Yaya;LIU Xiaoyun;LI Xiangrong
作者机构：
Medical Research&Biometrics Center,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China,102300
文献出处：
引用格式：
[1]DING Lijuan;YIN Lu;WANG Liping;SUN Yaya;LIU Xiaoyun;LI Xiangrong-.Effectiveness of redcore lotion in patients with vulvovaginal candidiasis:a systematic review and Meta-analysis)[J].中医杂志（英文版）,2022(04):487-492
A类：
redcore,lotion,Redcore,miconazole,reduC
B类：
Effectiveness,patients,vulvovaginal,candidiasis,systematic,review,analysis,OBJECTIVE,To,summarize,evaluate,effectiveness,safety,treating,VVC,using,randomized,controlled,trials,METHODS,literature,search,was,performed,five,English,three,Chinese,electronic,databases,October,Randomized,treatment,were,included,only,studies,which,compared,plus,alone,Relative,risk,RR,confidence,intervals,used,RESULTS,Seven,involving,suffering,from,WC,identified,pregnant,women,Combination,more,symptomatic,episodes,than,respect,cure,rate,fungal,culture,negative,Subgroup,analyses,also,showed,that,combination,had,superior,outcomes,Additionally,observed,adverse,events,lower,medication,CONCLUSIONS,Though,overall,quality,individual,significantly,improve,clinical
AB值：
0.443918
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