典型文献
PRMT5 confers lipid metabolism reprogramming,tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours
文献摘要：
The protein arginine methyltransferase 5(PRMT5),which is highly expressed in tumour tissues,plays a crucial role in cancer development.However,the mechanism by which PRMT5 promotes cancer growth is poorly understood.Here,we report that PRMT5 contributes to lipid metabolism reprogramming,tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.Mass spectrometric analysis identified PRMT5 lysine 387 as its succinylation site.Moreover,the desuccinylation of PRMT5 K387 enhances the methyltransferase activity of PRMT5.SIRT7 catalyses the desuccinylation of PRMT5 in cells.The SIRT7-mediated dessuccinylation of PRMT5 lysine 387 fails to bind to STUB1,decreasing PRMT5 ubiquitination and increasing the interaction between PRMT5 and Mep50,which promotes the formation of the PRMT5-Mep50 octamer.The PRMT5-Mep50 octamer increases PRMT5 methyltransferase activity,leading to arginine methylation of SREBP1a.The symmetric dimethylation of SREBP1a increases the levels of cholesterol,fatty acid,and triglyceride biogenesis in the cells,escaping degradation through the ubiquitin-proteasome pathway.Functionally,the desuccinylation of PRMT5 K387 promotes lipid metabolism reprogramming,tumour growth and metastasis in vitro and in vivo in tumours.
文献关键词：
中图分类号：
作者姓名：
Hong-feng Yuan;Man Zhao;Li-na Zhao;Hao-lin Yun;Guang Yang;Yu Geng;Yu-fei Wang;Wei Zheng;Ying Yuan;Tian-qiang Song;Jun-qi Niu;Xiao-dong Zhang
作者机构：
Department of Gastrointestinal Cancer Biology,Tianjin Cancer Institute,Liver Cancer Center,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin 300060,China;Department of Cancer Research,College of Life Sciences,Nankai University,Tianjin 300071,China;Department of Hepatobiliary Cancer,Liver Cancer Research Center,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China;Department of Hepatology,the First Hospital,Jilin University,Jilin 130021,China
文献出处：
引用格式：
[1]Hong-feng Yuan;Man Zhao;Li-na Zhao;Hao-lin Yun;Guang Yang;Yu Geng;Yu-fei Wang;Wei Zheng;Ying Yuan;Tian-qiang Song;Jun-qi Niu;Xiao-dong Zhang-.PRMT5 confers lipid metabolism reprogramming,tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours)[J].中国药理学报（英文版）,2022(09):2373-2385
A类：
desuccinylation,K387,catalyses,dessuccinylation,Mep50,SREBP1a,dimethylation
B类：
PRMT5,confers,lipid,metabolism,reprogramming,growth,metastasis,depending,SIRT7,mediated,tumours,protein,arginine,methyltransferase,which,highly,expressed,tissues,plays,crucial,role,cancer,development,However,mechanism,by,promotes,poorly,understood,Here,report,that,contributes,Mass,spectrometric,analysis,identified,lysine,its,site,Moreover,enhances,activity,cells,fails,bind,STUB1,decreasing,ubiquitination,increasing,interaction,between,formation,octamer,increases,leading,symmetric,levels,cholesterol,fatty,acid,triglyceride,biogenesis,escaping,degradation,through,proteasome,pathway,Functionally,vitro,vivo
AB值：
0.361498
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