典型文献
Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells
文献摘要：
Systemic sclerosis(SSc)is a life-threatening chronic connective tissue disease with the characteristics of skin fibrosis,vascular injury,and inflammatory infiltrations.Though inhibition of phosphodiesterase 4(PDE4)has been turned out to be an effective strategy in suppressing inflammation through promoting the accumulation of intracellular cyclic adenosine monophosphate(cAMP),little is known about the functional modes of inhibiting PDE4 by apremilast on the process of SSc.The present research aimed to investigate the therapeutic effects and underlying mechanism of apremilast on SSc.Herein,we found that apremilast could markedly ameliorate the pathological manifestations of SSc,including skin dermal thickness,deposition of collagens,and increased expression of α-SMA.Further study demonstrated that apremilast suppressed the recruitment and activation of macrophages and T cells,along with the secretion of inflammatory cytokines,which accounted for the effects of apremilast on modulating the pro-fibrotic processes.Interestingly,apremilast could dose-dependently inhibit the activation of M1 and T cells in vitro through promoting the phosphorylation of CREB.In summary,our research suggested that inhibiting PDE4 by apremilast might provide a novel therapeutic option for clinical treatment of SSc patients.
文献关键词：
中图分类号：
作者姓名：
Qiu-kai Lu;Chen Fan;Cai-gui Xiang;Bing Wu;Hui-min Lu;Chun-Ian Feng;Xiao-qian Yang;Heng Li;Wei Tang
作者机构：
Laboratory of Anti-inflammation and Immunopharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Qiu-kai Lu;Chen Fan;Cai-gui Xiang;Bing Wu;Hui-min Lu;Chun-Ian Feng;Xiao-qian Yang;Heng Li;Wei Tang-.Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells)[J].中国药理学报（英文版）,2022(02):376-386
A类：
B类：
Inhibition,PDE4,by,apremilast,attenuates,skin,fibrosis,through,directly,suppressing,activation,M1,cells,Systemic,sclerosis,SSc,life,threatening,chronic,connective,tissue,disease,characteristics,vascular,injury,inflammatory,infiltrations,Though,inhibition,phosphodiesterase,has,been,turned,effective,strategy,inflammation,promoting,accumulation,intracellular,cyclic,adenosine,monophosphate,cAMP,little,known,about,functional,modes,inhibiting,present,research,aimed,investigate,therapeutic,effects,underlying,mechanism,Herein,we,found,that,could,markedly,ameliorate,pathological,manifestations,including,dermal,thickness,deposition,collagens,increased,expression,SMA,Further,study,demonstrated,suppressed,recruitment,macrophages,along,secretion,cytokines,which,accounted,modulating,fibrotic,processes,Interestingly,dose,dependently,vitro,phosphorylation,CREB,summary,our,suggested,might,provide,novel,option,clinical,treatment,patients
AB值：
0.607013
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
