典型文献
(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer's disease transgenic mice
文献摘要：
in our previous studies,we have shown that (D-Ser2) oxyntomodulin (Oxm),a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide,protects hippocampal neurons against Aβ1-42-induced cytotoxicity,and stabilizes the calcium homeostasis and mitochondrial membrane potential of hippocampal neurons.Additionally,we have demonstrated that (D-Ser2) Oxm improves cognitive decline and reduces the deposition of amyloid-beta in Alzheimer's disease model mice.However,the protective mechanism remains unclear.In this study,we showed that 2 weeks of intraperitoneal administration of (D-Ser2) Oxm ameliorated the working memory and fear memory impairments of 9-month-old 3xTg Alzheimer's disease model mice.In addition,electrophysiological data recorded by a wireless multichannel neural recording system implanted in the hippocampal CA1 region showed that (D-Ser2) Oxm increased the power of the theta rhythm.In addition,(D-Ser2) Oxm treatment greatly increased the expression level of synaptic-associated proteins SYP and PSD-95 and increased the number of dendritic spines in 3×Tg Alzheimer's disease model mice.These findings suggest that (D-Ser2) Oxm improves the cognitive function of Alzheimer's disease transgenic mice by recovering hippocampal synaptic function and theta rhythm.
文献关键词：
中图分类号：
作者姓名：
Guang-Zhao Yang;Qi-Chao Gao;Wei-Ran Li;Hong-Yan Cai;Hui-Min Zhao;Jian-Ji Wang;Xin-Rui Zhao;Jia-Xin Wang;Mei-Na Wu;Jun Zhang;Christian H(o)lscher;Jin-Shun Qi;Zhao-Jun Wang
作者机构：
Department of Cardiovascular Medicine,the First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China;Department of Physiology,Shanxi Medical University;Key Laboratory of Cellular Physiology,Ministry of Education;Key Laboratory of Cellular Physiology in Shanxi Province,Taiyuan,Shanxi Province,China;Department of Microbiology and Immunology,Shanxi Medical University,Taiyuan,Shanxi Province,China;Functional Laboratory Center,Shanxi Medical University,Taiyuan,Shanxi Province,China;Research and Experimental Center,Henan University of Chinese Medicine,Zhengzhou,Henan Province,China
文献出处：
引用格式：
[1]Guang-Zhao Yang;Qi-Chao Gao;Wei-Ran Li;Hong-Yan Cai;Hui-Min Zhao;Jian-Ji Wang;Xin-Rui Zhao;Jia-Xin Wang;Mei-Na Wu;Jun Zhang;Christian H(o)lscher;Jin-Shun Qi;Zhao-Jun Wang-.(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer's disease transgenic mice)[J].中国神经再生研究（英文版）,2022(09):2072-2078
A类：
Ser2,oxyntomodulin,Oxm,GLP1R,3xTg
B类：
recovers,hippocampal,synaptic,structure,theta,rhythm,Alzheimer,disease,transgenic,mice,our,previous,studies,have,shown,that,glucagon,like,peptide,receptor,GCGR,dual,agonist,protects,neurons,against,induced,cytotoxicity,stabilizes,calcium,homeostasis,mitochondrial,membrane,potential,Additionally,demonstrated,improves,cognitive,decline,reduces,deposition,amyloid,beta,model,However,protective,mechanism,remains,unclear,In,this,study,showed,weeks,intraperitoneal,administration,ameliorated,working,memory,fear,impairments,month,old,addition,electrophysiological,data,recorded,by,wireless,multichannel,neural,recording,system,implanted,CA1,region,increased,power,treatment,greatly,expression,level,associated,proteins,SYP,PSD,number,dendritic,spines,These,findings,suggest,function,recovering
AB值：
0.497778
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