典型文献
Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease
文献摘要：
Metabolic-associated fatty liver disease(MAFLD)is the most common metabolic disease with a global prevalence of 25％.While MAFLD is serious and incurable at the later stage,it can be controlled or reversed at the early stage of hepatosteatosis originating from unhealthy diets.Recent laboratory evidence implicates a critical role of the mammalian target of rapamycin(mTOR)-autophagy signaling pathway in the pathogenesis of MAFLD induced by a high-fructose diet mimicking the overconsumption of sugar in humans.This review discusses the possible molecular mechanisms of mTOR-autophagy-endoplasmic reticulum(ER)stress in MAFLD.Based on careful analysis of recent studies,we suggest possible new therapeutic concepts or targets that can be explored for the discovery of new anti-MAFLD drugs.
文献关键词：
中图分类号：
作者姓名：
Ya-lin Wang;Xiu Zhou;Dong-li Li;Ji-ming Ye
作者机构：
Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China ;Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China;School of Health and Biomedical Sciences,RMIT University,Melbourne,VIC,Australia
文献出处：
引用格式：
[1]Ya-lin Wang;Xiu Zhou;Dong-li Li;Ji-ming Ye-.Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease)[J].中国药理学报（英文版）,2022(01):10-14
A类：
hepatosteatosis,overconsumption
B类：
Role,mTOR,autophagy,ER,stress,pathway,high,fructose,induced,metabolic,associated,fatty,liver,disease,Metabolic,MAFLD,most,common,global,prevalence,While,serious,incurable,later,stage,can,be,controlled,reversed,early,originating,from,unhealthy,diets,Recent,laboratory,evidence,implicates,critical,role,mammalian,rapamycin,signaling,pathogenesis,by,mimicking,sugar,humans,This,review,discusses,possible,molecular,mechanisms,endoplasmic,reticulum,Based,careful,analysis,recent,studies,we,suggest,new,therapeutic,concepts,targets,that,explored,discovery,anti,drugs
AB值：
0.613019
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