典型文献
Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia
文献摘要：
Reduced levels of retinal dopamine,a key regulator of eye development,are associated with exper-imental myopia in various species,but are not seen in the myopic eyes of C57BL/6 mice,which are deficient in melatonin,a neurohormone having extensive interactions with dopamine.Here,we examined the relationship between form-deprivation myopia(FDM)and retinal dopamine levels in melatonin-proficient CBA/CaJ mice.We found that these mice exhibited a myopic refractive shift in form-deprived eyes,which was accompanied by altered retinal dopamine levels.When melatonin receptors were pharmacologically blocked,FDM could still be induced,but its magnitude was reduced,and retinal dopamine levels were no longer altered in FDM animals,indicating that melatonin-related changes in retinal dopa-mine levels contribute to FDM.Thus,FDM is mediated by both dopamine level-independent and melatonin-related dopamine level-dependent mechanisms in CBA/CaJ mice.The previously reported unaltered retinal dopamine levels in myopic C57BL/6 mice may be attributed to melatonin deficiency.
文献关键词：
中图分类号：
作者姓名：
Kang-Wei Qian;Yun-Yun Li;Xiao-Hua Wu;Xue Gong;Ai-Lin Liu;Wen-Hao Chen;Zhe Yang;Ling-Jie Cui;Yun-Feng Liu;Yuan-Yuan Ma;Chen-Xi Yu;Furong Huang;Qiongsi Wang;Xiangtian Zhou;Jia Qu;Yong-Mei Zhong;Xiong-Li Yang;Shi-Jun Weng
作者机构：
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai 200032,China;Department of Immunology,School of Basic Medical Sciences,Anhui Medical University,Hefei 230032,China;Discipline of Neuroscience and Department of Anatomy and Physiology,College of Basic Medical Sciences,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;School of Ophthalmology and Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China
文献出处：
引用格式：
[1]Kang-Wei Qian;Yun-Yun Li;Xiao-Hua Wu;Xue Gong;Ai-Lin Liu;Wen-Hao Chen;Zhe Yang;Ling-Jie Cui;Yun-Feng Liu;Yuan-Yuan Ma;Chen-Xi Yu;Furong Huang;Qiongsi Wang;Xiangtian Zhou;Jia Qu;Yong-Mei Zhong;Xiong-Li Yang;Shi-Jun Weng-.Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia)[J].神经科学通报（英文版）,2022(09):992-1006
A类：
Myopia,neurohormone,CaJ
B类：
Altered,Retinal,Dopamine,Levels,Melatonin,proficient,Mouse,Model,Form,deprivation,Reduced,levels,retinal,dopamine,key,regulator,development,are,associated,exper,imental,myopia,various,species,not,seen,myopic,eyes,C57BL,mice,which,deficient,melatonin,having,extensive,interactions,Here,examined,relationship,between,form,FDM,CBA,We,found,that,these,exhibited,refractive,shift,deprived,was,accompanied,by,When,receptors,were,pharmacologically,blocked,could,still,induced,its,magnitude,reduced,longer,animals,indicating,related,changes,contribute,Thus,mediated,both,independent,mechanisms,previously,reported,unaltered,may,attributed,deficiency
AB值：
0.500334
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