典型文献
Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice
文献摘要：
Chronic stress leads to many psychiatric disor-ders,including social and anxiety disorders that are associated with over-activation of neurons in the basolat-eral amygdala (BLA).However,not all individuals develop psychiatric diseases,many showing considerable resilience against stress exposure.Whether BLA neuronal activity is involved in regulating an individual's vulnerability to stress remains elusive.In this study,using a mouse model of chronic social defeat stress (CSDS),we divided the mice into susceptible and resilient subgroups based on their social interaction behavior.Using in vivo fiber photometry and in vitro patch-clamp recording,we showed that CSDS persistently (after 20 days of recovery from stress)increased BLA neuronal activity in all the mice regardless of their susceptible or resilient nature,although impaired social interaction behavior was only observed in suscep-tible mice.Increased anxiety-like behavior,on the other hand,was evident in both groups.Notably,the CSDS-induced increase of BLA neuronal activity correlated well with the heightened anxiety-like but not the social avoid-ance behavior in mice.These findings provide new insight to our understanding of the role of neuronal activity in the amygdala in mediating stress-related psychiatric disorders.
文献关键词：
中图分类号：
作者姓名：
Shou-He Huang;Wei-Zhu Liu;Xia Qin;Chen-Yi Guo;Qing-Cheng Xiong;Yu Wang;Ping Hu;Bing-Xing Pan;Wen-Hua Zhang
作者机构：
Laboratory of Fear and Anxiety Disorders,Institutes of Life Science,Nanchang University,Nanchang 330031,China;Institute of Translational Medicine,Nanchang University,Nanchang 330001,China
文献出处：
引用格式：
[1]Shou-He Huang;Wei-Zhu Liu;Xia Qin;Chen-Yi Guo;Qing-Cheng Xiong;Yu Wang;Ping Hu;Bing-Xing Pan;Wen-Hua Zhang-.Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice)[J].神经科学通报（英文版）,2022(01):16-28
A类：
basolat,tible
B类：
Association,Increased,Amygdala,Activity,Stress,Induced,Anxiety,but,not,Social,Avoidance,Behavior,Mice,Chronic,stress,leads,many,psychiatric,including,social,anxiety,disorders,that,are,associated,activation,neurons,eral,amygdala,BLA,However,all,individuals,develop,diseases,showing,considerable,resilience,against,exposure,Whether,neuronal,activity,involved,regulating,vulnerability,remains,elusive,this,study,using,mouse,model,chronic,defeat,CSDS,divided,mice,into,susceptible,resilient,subgroups,their,interaction,behavior,Using,vivo,fiber,photometry,vitro,patch,clamp,recording,showed,persistently,after,days,recovery,from,increased,regardless,nature,although,impaired,was,only,observed,like,other,hand,evident,both,Notably,induced,correlated,well,heightened,avoid,These,findings,provide,new,insight,our,understanding,role,mediating
AB值：
0.570572
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
