典型文献
Picomolar antimalarial agent from a Chinese medicinal plant
文献摘要：
In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1-7) with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp.brachystachys by solid data acquired by diverse methods.Among them,compound 3 with an ECs0 value of 4.3 pM against the chloroquine-resistant Plasmodiumfalciparum is the most potent antimalarial agent reported hitherto,about 1,000-fold stronger than artemisinin.This article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.
文献关键词：
中图分类号：
作者姓名：
Bin Zhou;Flavia M.Zimbres;Joshua H.Butler;Cheng-Hui Xu;Reagan S.Haney;Yan Wu;Maria B.Cassera;Jian-Min Yue
作者机构：
State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Department of Biochemistry and Molecular Biology,Center for Tropical and Emerging Global Diseases (CTEGD),University of Georgia,Athens,Georgia 30602,United States
文献出处：
引用格式：
[1]Bin Zhou;Flavia M.Zimbres;Joshua H.Butler;Cheng-Hui Xu;Reagan S.Haney;Yan Wu;Maria B.Cassera;Jian-Min Yue-.Picomolar antimalarial agent from a Chinese medicinal plant)[J].中国科学:化学（英文版）,2022(01):82-86
A类：
Picomolar,Sarcandra,brachystachys,ECs0,Plasmodiumfalciparum
B类：
antimalarial,from,Chinese,medicinal,In,our,long,term,efforts,searching,agents,plants,seven,novel,dimeric,sesquiterpenoids,significant,activity,were,isolated,characterized,whole,glabra,subsp,by,data,acquired,diverse,methods,Among,them,compound,value,pM,against,chloroquine,resistant,most,potent,reported,hitherto,about,fold,stronger,than,artemisinin,This,article,further,consolidates,refines,previously,delineated,structure,relationship,this,class
AB值：
0.627043
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
