典型文献
Characterization and structure analysis of the heterosolvate of erythromycin thiocyanate
文献摘要：
Erythromycin thiocyanate is widely used for the production of other macrolide antibiotics.In this work,a novel heterosolvate of this pharmaceutical compound has been obtained and characterized for the first time,which was transformed from the dihydrate form in the acetone solvent through evaporation crys-tallization.Thermal behavior together with compositional analysis revealed that both water and acetone molecules participated in the formation of the crystal lattice which is rarely reported before.The general chemical name of the heterosolvate may be defined as erythromycin thiocyanate sesquihydrate hemiace-tonate.Furthermore,studies on solid-state spectral analysis provided strong evidence of intermolecular hydrogen bonds in heterosolvate crystals.According to the crystal structure determined by single crystal X-ray diffraction,the formation mechanism of the heterosolvate is proposed in which strong multi-hydrogen bondings between water and solute molecules form the layer structure.While acetone mole-cules form single-hydrogen bonds with solutes and reside in channels between layers.This well explains why acetone solvent is easy to escape from the crystal structure during desolvation.
文献关键词：
中图分类号：
作者姓名：
Yuanjie Li;Qiuxiang Yin;Meijing Zhang;Ying Bao;Baohong Hou;Jingkang Wang;Jiting Huang;Ling Zhou
作者机构：
School of Chemical Engineering and Technology,State Key Laboratory of Chemical Engineering,Tianjin University,Tianjin 300350,China;Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin),Tianjin 300072,China;Luoxin Pharmaceutical(Shanghai)Co.,Ltd.,Shanghai 201203,China
文献出处：
引用格式：
[1]Yuanjie Li;Qiuxiang Yin;Meijing Zhang;Ying Bao;Baohong Hou;Jingkang Wang;Jiting Huang;Ling Zhou-.Characterization and structure analysis of the heterosolvate of erythromycin thiocyanate)[J].中国化学工程学报（英文版）,2022(04):268-274
A类：
heterosolvate,sesquihydrate,hemiace,tonate,bondings
B类：
Characterization,structure,analysis,erythromycin,thiocyanate,Erythromycin,widely,used,production,other,macrolide,antibiotics,In,this,work,novel,pharmaceutical,compound,has,been,obtained,characterized,first,which,was,transformed,from,dihydrate,acetone,solvent,through,evaporation,tallization,Thermal,behavior,together,compositional,revealed,that,both,water,molecules,participated,formation,lattice,rarely,reported,before,general,chemical,name,may,defined,Furthermore,studies,solid,state,spectral,provided,strong,evidence,intermolecular,hydrogen,bonds,crystals,According,determined,by,single,ray,diffraction,mechanism,proposed,multi,between,While,solutes,reside,channels,layers,This,well,explains,why,easy,escape,during,desolvation
AB值：
0.527934
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