典型文献
A secretory phospholipase A2 of a fungal pathogen contributes to lipid droplet homeostasis,assimilation of insect-derived lipids,and repression of host immune responses
文献摘要：
Secretory phospholipase A2s(sPLA2s)are found in a wide range of organisms from bacteria to higher plants and animals and are involved in varied and cellular pro-cesses.However,roles of these enzymes in microbial pathogens remain unclear.Here,an sPLA2(BbPLA2)was characterized in the filamentous insect pathogenic fungus,Beau-veria bassiana.BbPLA2 was exclusively expressed in insect hemolymph-derived cells(hyphal bodies),and its expression was induced by insect-derived nutrients and lipids,and nutrient starvation.High levels of secretion of BbPLA2 were observed as well as its distri-bution in hyphal body lipid drops(LDs).Overexpression of BbPLA2 increased the ability of B.bassiana to utilize insect-derived nutrients and lipids,and promoted LD accumula-tion,indicating functions for BbPLA2 in mediating LD homeostasis and assimilation of insect-derived lipids.Strains overexpressing BbPLA2 showed moderately increased vir-ulence,including more efficient penetration of the insect cuticle and evasion of host im-mune responses as compared to the wild type strain.In addition,B.bassiana-activated host immune genes were downregulated in the BbPLA2 overexpression strain,but upregulated by infections with a ΔBbPLA2 strain.These data demonstrate that BbPLA2 contributes to LD homeostasis,assimilation of insect-derived lipids,and repression of host immune responses.
文献关键词：
中图分类号：
作者姓名：
Juan Deng;Zhuoyue Lu;Huifang Wang;Ning Li;Guimei Song;Qiankuan Zhu;Jingxin Sun;Yongjun Zhang
作者机构：
Biotechnology Research Center,Academy of Agricultural Sciences,Southwest University,Chongqing,China;College of Plant Protection,Southwest University,Chongqing,China
文献出处：
引用格式：
[1]Juan Deng;Zhuoyue Lu;Huifang Wang;Ning Li;Guimei Song;Qiankuan Zhu;Jingxin Sun;Yongjun Zhang-.A secretory phospholipase A2 of a fungal pathogen contributes to lipid droplet homeostasis,assimilation of insect-derived lipids,and repression of host immune responses)[J].中国昆虫科学（英文版）,2022(06):1685-1702
A类：
sPLA2s,BbPLA2,Beau,veria,ulence
B类：
secretory,phospholipase,fungal,contributes,droplet,homeostasis,assimilation,insect,derived,lipids,repression,host,immune,responses,Secretory,found,wide,range,organisms,from,bacteria,higher,plants,animals,involved,varied,cellular,cesses,However,roles,these,enzymes,microbial,pathogens,remain,unclear,Here,was,characterized,filamentous,pathogenic,fungus,bassiana,exclusively,expressed,hemolymph,cells,hyphal,bodies,its,induced,by,nutrients,starvation,High,levels,secretion,were,observed,well,distri,bution,body,drops,LDs,Overexpression,increased,ability,utilize,promoted,accumula,indicating,functions,mediating,Strains,overexpressing,showed,moderately,vir,including,more,efficient,penetration,cuticle,evasion,compared,wild,type,strain,In,addition,activated,genes,downregulated,overexpression,upregulated,infections,These,data,demonstrate,that
AB值：
0.490408
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
