典型文献
Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia:a multi-centric randomized clinical trial
文献摘要：
We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial(NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4％with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8％by one course;it increased to 59.3％after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1％,95％confidence interval(CI)-19.4％to 9.2％,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3％)was similar to that of the control(95.2％,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7％by one course,which increased to 89.1％after subsequent multi-course,with non-inferiority(difference 24.7％,95％CI 12.8％-36.6％,P＜0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1％vs.95.2％,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN.
文献关键词：
中图分类号：
作者姓名：
Lili Chen;Ling Xi;Jie Jiang;Rutie Yin;Pengpeng Qu;Xiuqin Li;Xiaoyun Wan;Yaxia Chen;Dongxiao Hu;Yuyan Mao;Zimin Pan;Xiaodong Cheng;Xinyu Wang;Qingli Li;Danhui Weng;Xi Zhang;Hong Zhang;Quanhong Ping;Xiaomei Liu;Xing Xie;Beihua Kong;Ding Ma;Weiguo Lu
作者机构：
Department of Gynecological Oncology,Women's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Obstetrics and Gynecology,Qilu Hospital of Shandong University,Jinan 250012,China;Department of Obstetrics and Gynecology,West China Second University Hospital of Sichuan University,Chengdu 610041,China;Key Laboratory of Birth Defects and Related Disease of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China;Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300052,China;Shengjing Hospital of China Medical University,Shenyang 110021,China
文献出处：
引用格式：
[1]Lili Chen;Ling Xi;Jie Jiang;Rutie Yin;Pengpeng Qu;Xiuqin Li;Xiaoyun Wan;Yaxia Chen;Dongxiao Hu;Yuyan Mao;Zimin Pan;Xiaodong Cheng;Xinyu Wang;Qingli Li;Danhui Weng;Xi Zhang;Hong Zhang;Quanhong Ping;Xiaomei Liu;Xing Xie;Beihua Kong;Ding Ma;Weiguo Lu-.Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia:a multi-centric randomized clinical trial)[J].医学前沿,2022(02):276-284
A类：
dactinomycin,NCT01823315,MTX+dactinomycin,ACTD,MTX+ACTD
B类：
Chemotherapy,initiation,single,course,methotrexate,alone,combined,versus,multi,risk,gestational,trophoblastic,neoplasia,centric,randomized,clinical,trial,We,aimed,evaluate,effectiveness,safety,initial,regimens,patients,GTN,In,this,were,analyzed,Patients,allocated,three,initiated,control,arm,primary,endpoint,was,complete,remission,CR,by,drug,For,increased,after,subsequent,inferiority,difference,confidence,interval,After,further,treatment,similar,that,which,It,Four,experienced,recurrence,death,during,year,follow,up,demonstrated,chemotherapy,may,be,alternative
AB值：
0.355019
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