典型文献
Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic inheritance of multiple diseases
文献摘要：
Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the offspring.However,studies that explore the mechanisms that meditate this transmission are rare.Recently,small noncoding RNAs(sncRNAs)in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure,and the methodology of microinjection of isolated total RNA or sncRNAs or synthetically identified sncRNAs gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male line.Hence,by reviewing relevant literature,this study intends to answer the following research concepts:(1)paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncRNAs,(2)potential role of paternal spermatozoal sncRNAs during the intergenerational inheritance process,and(3)the potential mechanism by which spermatozoal sncRNAs meditate intergenerational inheritance.In summary,increased attention highlights the hidden wonder of spermatozoal sncRNAs during intergenerational inheritance.Therefore,in the future,more studies should focus on the origin of RNA alteration,the target of RNA regulation,and how sncRNA regulation during embryonic development can be sustained even in adult offspring.
文献关键词：
中图分类号：
作者姓名：
Xin Yin;Azhar Anwar;Yanbo Wang;Huanhuan Hu;Gaoli Liang;Chenyu Zhang
作者机构：
Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy,State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology,Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology,NJU Advanced Institute of Life Sciences(NAILS),School of Life Sciences,Nanjing University,Nanjing 210023,China
文献出处：
引用格式：
[1]Xin Yin;Azhar Anwar;Yanbo Wang;Huanhuan Hu;Gaoli Liang;Chenyu Zhang-.Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic inheritance of multiple diseases)[J].医学前沿,2022(02):176-184
A类：
spermatozoal,meditates,meditate
B类：
Paternal,environmental,exposure,induced,small,noncoding,alteration,intergenerational,epigenetic,inheritance,multiple,diseases,Studies,human,mammalian,have,revealed,that,can,affect,paternal,health,conditions,well,those,offspring,However,studies,explore,mechanisms,this,transmission,rare,Recently,sncRNAs,seemed,crucial,due,their,response,methodology,microinjection,isolated,total,synthetically,identified,gradually,lifted,veil,regulation,during,along,male,line,Hence,by,reviewing,relevant,literature,study,intends,answer,following,research,concepts,factors,be,passed,attributed,potential,role,process,which,In,summary,increased,attention,highlights,hidden,wonder,Therefore,future,more,should,focus,origin,target,how,embryonic,development,sustained,even,adult
AB值：
0.480273
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