典型文献
Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy
文献摘要：
Dear Editor,
Spinal and bulbar muscular atrophy(SBMA)or Kennedy's disease is a rare X-linked,recessive,lower motor neuron disease caused by a CAG repeat expansion within the first exon of the androgen receptor(AR)gene.Instability of the CAG-triplet repeat impacts AR function;therefore,men with SBMA are thought to be at a very low risk of prostate cancer.We previously reported a case of high-risk prostate cancer with SBMA(repeat length 46).1 Here,we present the follow-up of this patient along with investigation of his genetic background.
文献关键词：
中图分类号：
作者姓名：
Hiroshi Hongo;Takeo Kosaka;Hideyuki Hayashi;Kohei Nakamura;Hiroshi Nishihara;Shuji Mikami;Himisha Beltran;Mototsugu Oya
作者机构：
Department of Urology,Keio University School of Medicine,35 Shinanomachi,Shinjuku-ku,Tokyo 160-8582,Japan;Genomics Unit,Keio Cancer Center,Keio University School of Medicine,35 Shinanomachi,Shinjuku-ku,Tokyo 160-8582,Japan;Division of Diagnostic Pathology,Keio University Hospital,35 Shinanomachi,Shinjuku-ku,Tokyo 160-8582,Japan;Department of Medical Oncology,Dana-Farber Cancer Institute,450 Brookline Avenue,Boston,MA 02215,USA
文献出处：
引用格式：
[1]Hiroshi Hongo;Takeo Kosaka;Hideyuki Hayashi;Kohei Nakamura;Hiroshi Nishihara;Shuji Mikami;Himisha Beltran;Mototsugu Oya-.Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy)[J].亚洲男性学杂志（英文版）,2022(01):116-118
A类：
bulbar,
Spinal
B类：
Germline,BRCA2,mutation,case,aggressive,prostate,cancer,accompanied,by,spinal,muscular,atrophy,Dear,Editor,SBMA,Kennedy,disease,rare,linked,recessive,lower,motor,neuron,caused,CAG,repeat,expansion,within,first,exon,androgen,receptor,Instability,triplet,impacts,function,therefore,men,thought,be,very,risk,We,previously,reported,high,length,Here,present,follow,up,this,patient,along,investigation,genetic,background
AB值：
0.619202
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
