Background:We examined the associations of cardiorespiratory fitness(CRF)and white blood cell count(WBC)with mortality outcomes.Methods:A total of 52,056 apparently healthy adults completed a comprehensive health examination,including a maximal treadmill test and blood chemistry analyses.CRF was categorized as high,moderate,or low by age and sex;WBC was categorized as sex-specific quartiles.Results:During 17.8±9.5 years(mean±SD)of follow-up,a total of 4088 deaths occurred.When regressed jointly,significantly decreased all-cause mortality across CRF categories was observed within each quartile of WBC in men.Within WBC Quartile 1,all-cause mortality hazard ratios(HRs)with a 95％confidence interval(95％CI)were 1.0(referent),1.29(95％CI:1.06-1.57),and 2.03(95％CI:1.42-2.92)for high,moder-ate,and low CRF categories,respectively(p for trend＜0.001).Similar trends were observed in the remaining 3 quartiles.With the exception of cardiovascular disease(CVD)mortality within Quartile 1(p for trend=0.743),there were also similar trends across CRF categories within WBC quartiles in men for both CVD and cancer mortality(p for trend＜0.01 for all).For women,there were no significant trends across CRF catego-ries for mortality outcomes within Quartiles 1-3.However,we observed significantly decreased all-cause mortality across CRF categories within WBC Quartile 4(HR=1.05(95％CI:0.76-1.44),HR=1.63(95％CI:1.20-2.21),and HR=1.87(95％CI:1.29-2.69)for high,moderate,and low CRF,respectively(p for trend=0.002)).Similar trends in women were observed for CVD and cancer mortality within WBC Quartile 4 only.Conclusion:There are strong joint associations between CRF,WBC,and all-cause,CVD,and cancer mortality in men;these associations are less consistent in women.

Stephen W.Farrell;David Leonard;Kerem Shuval;Laura F.DeFina;Carolyn E.Barlow;Andjelka Pavlovic;William L.Haskell

Research Division,The Cooper Institute,Dallas,TX 75230,USA;Department of Medicine,Stanford University,Palo Alto,CA 94305,USA

运动与健康科学（英文）

[1]Stephen W.Farrell;David Leonard;Kerem Shuval;Laura F.DeFina;Carolyn E.Barlow;Andjelka Pavlovic;William L.Haskell-.Cardiorespiratory fitness,white blood cell count,and mortality in men and women)[J].运动与健康科学（英文）,2022(05):605-612

Cardiorespiratory,Quartile,referent,catego,Quartiles

fitness,white,blood,cell,count,mortality,women,Background,We,examined,associations,cardiorespiratory,CRF,WBC,outcomes,Methods,total,apparently,healthy,adults,completed,comprehensive,examination,including,maximal,treadmill,test,chemistry,analyses,was,categorized,high,moderate,by,age,sex,specific,quartiles,Results,During,years,mean,follow,up,deaths,occurred,When,regressed,jointly,significantly,decreased,all,cause,across,categories,observed,within,each,Within,hazard,ratios,HRs,confidence,interval,were,respectively,Similar,trends,remaining,exception,cardiovascular,disease,CVD,there,also,similar,both,cancer,For,no,However,only,Conclusion,There,strong,between,these,less,consistent

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