典型文献
Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease
文献摘要：
Aging is by far the most prominent risk factor for Alzheimer's disease(AD),and both aging and AD are associated with apparent metabolic alterations.As developing effective therapeutic interven-tions to treat AD is clearly in urgent need,the impact of modulating whole-body and intracellular meta-bolism in preclinical models and in human patients,on disease pathogenesis,have been explored.There is also an increasing awareness of differential risk and potential targeting strategies related to biological sex,microbiome,and circadian regulation.As a major part of intracellular metabolism,mitochondrial bioen-ergetics,mitochondrial quality-control mechanisms,and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions.This review summarizes and highlights these ef-forts.
文献关键词：
中图分类号：
作者姓名：
Steven N.Austad;Scott Ballinger;Thomas W.Buford;Christy S.Carter;Daniel L.Smith Jr;Victor Darley-Usmar;Jianhua Zhang
作者机构：
Department of Biology,University of Alabama at Birmingham,Birmingham,AL 35294,USA;Department of Pathology,University of Alabama at Birmingham,Birmingham,AL 35294,USA;Department of Medicine,University of Alabama at Birmingham,Birmingham,AL 35294,USA;Department of Nutrition Sciences,University of Alabama at Birmingham,Birmingham,AL 35294,USA
文献出处：
引用格式：
[1]Steven N.Austad;Scott Ballinger;Thomas W.Buford;Christy S.Carter;Daniel L.Smith Jr;Victor Darley-Usmar;Jianhua Zhang-.Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease)[J].药学学报（英文版）,2022(02):511-531
A类：
bioenergetics,bioen,ergetics,forts
B类：
Targeting,whole,body,metabolism,mitochondrial,drug,development,Alzheimer,disease,Aging,by,far,most,prominent,risk,AD,both,aging,associated,apparent,metabolic,alterations,developing,effective,therapeutic,treat,clearly,urgent,need,impact,modulating,intracellular,preclinical,models,human,patients,pathogenesis,have,been,explored,There,also,increasing,awareness,differential,potential,targeting,strategies,related,biological,sex,microbiome,circadian,regulation,major,part,quality,control,mechanisms,linked,inflammatory,responses,considered,interventions,This,review,summarizes,highlights,these
AB值：
0.584359
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
