Dry powder inhalers(DPIs)had been widely used in lung diseases on account of direct pul-monary delivery,good drug stability and satisfactory patient compliance.However,an indistinct under-standing of pulmonary delivery processes(PDPs)hindered the development of DPIs.Most current evaluation methods explored the PDPs with over-simplified models,leading to uncompleted investiga-tions of the whole or partial PDPs.In the present research,an innovative modular process analysis plat-form(MPAP)was applied to investigate the detailed mechanisms of each PDP of DPIs with different carrier particle sizes(CPS).The MPAP was composed of a laser particle size analyzer,an inhaler device,an artificial throat and a pre-separator,to investigate the fluidization and dispersion,transportation,detachment and deposition process of DPIs.The release profiles of drug,drug aggregation and carrier were monitored in real-time.The influence of CPS on PDPs and corresponding mechanisms were explored.The powder properties of the carriers were investigated by the optical profiler and Freeman Technology four powder rheometer.The next generation impactor was employed to explore the aerosol-ization performance of DPIs.The novel MPAP was successfully applied in exploring the comprehensive mechanism of PDPs,which had enormous potential to be used to investigate and develop DPIs.

Yingtong Cui;Ying Huang;Xuejuan Zhang;Xiangyun Lu;Jun Xue;Guanlin Wang;Ping Hu;Xiao Yue;Ziyu Zhao;Xin Pan;Chuanbin Wu

School of Pharmaceutical Science,Jinan University,Guangzhou 510006,China;School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;Micromeritics Instrument(Shanghai)Ltd.,Shanghai 200135,China;MEGGLE Group Shanghai Representative Office,Shanghai 201315,China;Department of Pharmacology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China

药学学报（英文版）

[1]Yingtong Cui;Ying Huang;Xuejuan Zhang;Xiangyun Lu;Jun Xue;Guanlin Wang;Ping Hu;Xiao Yue;Ziyu Zhao;Xin Pan;Chuanbin Wu-.A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes)[J].药学学报（英文版）,2022(01):437-450

DPIs,inhalers,PDPs,uncompleted

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