典型文献
Long noncoding RNA GAS5 attenuates cigarette smoke-induced airway remodeling by regulating miR-217-5p/PTEN axis
文献摘要：
Airway remodeling is a remarkable pathological characteristic of chronic obstructive pulmonary disease(COPD),and long noncoding RNAs have been demonstrated to participate in COPD development and pathogenesis.Here,we investigate the role of long noncoding RNA GAS5 in cigarette smoke(CS)-induced airway remodeling.GAS5 expression is significantly lower in lung tissues of CS-exposed mice than in tissues of control mice without ex-posure to CS.Forced GAS5 overexpression suppresses CS-induced airway inflammation and remodeling.GAS5 overexpression also inhibits CS extract-induced inflammatory-cytokine expression and fibroblast activation in vitro.Regarding the mechanism,GAS5 acts as a sponge of miR-217-5p,thereby increasing PTEN expression.MiR-217-5p overexpression and PTEN knockdown separately reverse the inhibitory effects of GAS5 overexpression on the inflammatory-cytokine expression and fibroblast activation.Collectively,these results suggest that GAS5 can suppress airway inflammation and fibroblast activation by regulating miR-217-5p/PTEN axis,which may help de-velop novel therapeutic strategies against COPD.
文献关键词：
中图分类号：
作者姓名：
Yong Du;Yi Ding;Tianyun Shi;Wei He;Jingjing Feng;Zhoufang Mei;Xuru Chen;Xintong Feng;Xiaohua Zhang;Zhijun Jie
作者机构：
Department of Pulmonary and Critical Care Medicine,Shanghai Fifth People's Hospital,Fudan University,Shanghai 200240,China
文献出处：
引用格式：
[1]Yong Du;Yi Ding;Tianyun Shi;Wei He;Jingjing Feng;Zhoufang Mei;Xuru Chen;Xintong Feng;Xiaohua Zhang;Zhijun Jie-.Long noncoding RNA GAS5 attenuates cigarette smoke-induced airway remodeling by regulating miR-217-5p/PTEN axis)[J].生物化学与生物物理学报（英文版）,2022(07):931-939
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Long,noncoding,GAS5,attenuates,cigarette,smoke,induced,airway,remodeling,regulating,miR,5p,PTEN,axis,Airway,remarkable,pathological,characteristic,chronic,obstructive,pulmonary,disease,COPD,long,RNAs,have,been,demonstrated,participate,development,pathogenesis,Here,investigate,role,CS,significantly,lower,lung,tissues,exposed,mice,than,control,without,posure,Forced,overexpression,suppresses,inflammation,also,inhibits,extract,inflammatory,cytokine,fibroblast,activation,vitro,Regarding,mechanism,acts,sponge,thereby,increasing,MiR,knockdown,separately,reverse,inhibitory,effects,Collectively,these,results,suggest,that,which,may,help,novel,therapeutic,strategies,against
AB值：
0.516346
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