典型文献
Foe and friend in the COVID-19-associated acute kidney injury:an insight on intrarenal renin-angiotensin system
文献摘要：
Since the first reported case in December of 2019,the coronavirus disease 2019(COVID-19)has became an inter-national public health emergency.So far,there are more than 228,206,384 confirmed cases including 4,687,066 deaths.Kidney with high expression of angiotensin-converting enzyme 2(ACE2)is one of the extrapulmonary target organs affected in patients with COVID-19.Acute kidney injury(AKI)is one of the independent risk factors for the death of COVID-19 patients.The imbalance between ACE2-Ang(1-7)-MasR and ACE-Ang Ⅱ-AT1R axis in the kidney may contribute to COVID-19-associated AKI.Although series of research have shown the inconsistent effects of multiple common RAS inhibitors on ACE2 expression and enzyme activity,most of the retrospective cohort studies indicated the safety and protective effects of ACEI/ARB in COVID-19 patients.This review article highlights the current knowledge on the possible involvement of intrarenal RAS in COVID-19-associated AKI with a primary focus on the opposing effects of ACE2-Ang(1-7)-MasR and ACE-Ang Ⅱ-AT1R signaling in the kidney.Human re-combinant soluble ACE2 or ACE2 variants with preserved ACE2-enzymatic activity may be the best options to improve COVID-19-associated AKI.
文献关键词：
中图分类号：
作者姓名：
Chuanming Xu;Yanting Chen;Jun Yu
作者机构：
Translational Medicine Centre,Jiangxi University of Chinese Medicine,Nanchang,330002,China;Institute of Hypertension,Sun Yat-sen University School of Medicine,Guangzhou 510080,China;Center for Metabolic Disease Research and Department of Physiology,Lewis Katz School of Medicine,Temple University,Philadelphia,PA 19140,USA
文献出处：
引用格式：
[1]Chuanming Xu;Yanting Chen;Jun Yu-.Foe and friend in the COVID-19-associated acute kidney injury:an insight on intrarenal renin-angiotensin system)[J].生物化学与生物物理学报（英文版）,2022(01):1-11
A类：
Foe,combinant
B类：
friend,associated,acute,kidney,injury,insight,intrarenal,renin,angiotensin,system,Since,first,reported,December,coronavirus,disease,has,became,inter,national,public,health,emergency,So,far,there,more,than,confirmed,cases,including,deaths,Kidney,expression,converting,enzyme,ACE2,one,extrapulmonary,target,organs,affected,patients,Acute,AKI,independent,risk,factors,imbalance,between,Ang,MasR,AT1R,axis,may,contribute,Although,series,research,have,shown,inconsistent,effects,multiple,common,RAS,inhibitors,activity,most,retrospective,cohort,studies,indicated,safety,protective,ACEI,ARB,This,review,article,highlights,current,knowledge,possible,involvement,primary,focus,opposing,signaling,Human,soluble,variants,preserved,enzymatic,best,options,improve
AB值：
0.564696
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