BACKGROUND Intermediate coronary lesions (ICLs) are highly prevalent but ported mixed prognosis. Radial strain has been associated with plaque vulnerability, yet its role in predicting lesion progression is largely unknown. The purpose of this study was to determine the predictive value of angiography-derived radial wall strain (RWS) for progression of untreated non-culprit ICLs.METHODS Post-hoc analysis was conducted in a study cohort including 603 consecutive patients with 808 ICLs identified at index procedure with angiographic follow-up of up to two years. RWS analysis was performed on selected angiographic frames with minimal foreshortening and vessel overlap. Lesion progression was defined as ≥ 20％ increase in percent diameter stenosis. RESULTS Lesion progression occurred in 49 ICLs (6.1％) with a median follow-up period of 16.8 months. Maximal RWS (RWSmax), frequently located at the proximal and throat plaque regions, distinguished progressive ICLs from silent ones. The largest area under the curve value of 0.75 (95％ CI: 0.67–0.82, P < 0.001) was reached at the optimal RWSmax cutoff value of > 12.6％. Accor-ding to this threshold, 178 ICLs were classified as having a high strain pattern. Exposure to a high strain amplitude with RWSmax >12.6％ was independently associated with an increased risk of lesion progression (adjusted HR = 6.82, 95％ CI: 3.67–12.66, P <0.001). CONCLUSIONS Assessment of RWS from coronary angiography is feasible and provides independent prognostic value in pa-tients with untreated ICLs.

Zhi-Qing WANG;Bo XU;Chun-Ming LI;Chang-Dong GUAN;Yue CHANG;Li-Hua XIE;Su ZHANG;Jia-Yue HUANG;Patrick WSerruys;William Wijns;Liang-Long CHEN;Sheng-Xian TU

Department of Cardiology,Fujian Heart Medical Center,Fujian Institute of Coronary Heart Disease,Fujian Medical University Union Hospital,Fujian,China;Biomedical Instrument Institute,School of Biomedical Engineering,Shang-hai Jiao Tong University,Shanghai,China;Department of Cardiology,National Clinical Research Center for Cardiov-ascular Diseases,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Scien-ces and Peking Union Medical College,Beijing,China;The Lambe Institute for Translational Medicine and Curam,University of Galway,Galway,Ireland

老年心脏病学杂志（英文版）

[1]Zhi-Qing WANG;Bo XU;Chun-Ming LI;Chang-Dong GUAN;Yue CHANG;Li-Hua XIE;Su ZHANG;Jia-Yue HUANG;Patrick WSerruys;William Wijns;Liang-Long CHEN;Sheng-Xian TU-.Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis)[J].老年心脏病学杂志（英文版）,2022(12):937-948

foreshortening,RWSmax,Accor

Angiography,derived,radial,wall,strain,predicts,coronary,progression,culprit,intermediate,stenosis,BACKGROUND,Intermediate,lesions,ICLs,highly,prevalent,but,ported,mixed,prognosis,Radial,has,been,associated,plaque,vulnerability,yet,its,role,predicting,largely,unknown,purpose,this,study,was,determine,predictive,value,angiography,untreated,METHODS,Post,hoc,analysis,conducted,cohort,including,consecutive,patients,identified,procedure,angiographic,follow,up,two,years,performed,selected,frames,minimal,vessel,overlap,Lesion,defined,percent,diameter,RESULTS,occurred,median,period,months,Maximal,frequently,located,proximal,throat,regions,distinguished,progressive,from,silent,ones,largest,area,under,curve,reached,optimal,cutoff,threshold,were,classified,having,pattern,Exposure,amplitude,independently,increased,risk,adjusted,CONCLUSIONS,Assessment,feasible,provides,prognostic

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