典型文献
Haploidentical hematopoietic stem cell transplantation in severe aplastic anemia:time for long term and quality of life assessed studies
文献摘要：
Severe aplastic anemia(SAA)is a lethal disease that has been shown to be cured by allogeneic hematopoietic stem cell trans-plantation(HSCT)dating back to the transplant's early days[1].It is also the prototype of transplantation in its original means,as in HSCT for SAA the malfunctioning organ-the hematopoietic sys-tem in the bone marrow is replaced by a functional organ similarly to any other organ transplantation process.However,unlike any other organ transplantation procedure,in HSCT besides replacing the malfunctioning organ,additional organ is being transplanted(a new immune system)as the transplanted hematopoietic stem cell is the source for the new donor hematopoietic but also immune system[1].SAA-being a nonmalignant indication,relapse is not an issue,and thus there is no need for the graft versus tumor effect that is commonly associated with graft versus host disease(GVHD)in its acute and mostly chronic(c)form[2].cGVHD is asso-ciated with very high morbidity and has been shown to have detri-mental effects and be the major determinant of the post-HSCT long-term quality of life(QOL)and post-transplantation survivor-ship[3,4].Finally,the field of hematology and SAA in general and hematopoietic stem cell transplantation,in particular,suffers from a paucity of long-term follow-ups and studies that are crucial regarding HSCT-related long-term effects and toxicities including for example secondary malignancies[5].
文献关键词：
中图分类号：
作者姓名：
Arnon Nagler
作者机构：
The Division of Hematology,Bone Marrow Transplantation and the Hematooncology Center,Chaim Sheba Medical Center,Tel-Hashomer 52621,Israel;Tel-Aviv University and Sackler School of Medicine,Tel-Aviv 52621,Israel
文献出处：
引用格式：
[1]Arnon Nagler-.Haploidentical hematopoietic stem cell transplantation in severe aplastic anemia:time for long term and quality of life assessed studies)[J].科学通报（英文版）,2022(17):1743-1744
A类：
Haploidentical,malfunctioning
B类：
hematopoietic,cell,transplantation,severe,aplastic,anemia,long,quality,life,assessed,studies,Severe,SAA,lethal,disease,that,has,been,shown,cured,by,allogeneic,HSCT,dating,back,early,days,It,also,prototype,its,original,means,organ,bone,marrow,replaced,functional,similarly,any,other,process,However,unlike,procedure,besides,replacing,additional,being,transplanted,new,immune,system,source,donor,but,nonmalignant,indication,relapse,not,issue,thus,there,need,graft,versus,tumor,commonly,associated,host,acute,mostly,chronic,form,cGVHD,very,high,morbidity,have,detri,mental,effects,major,determinant,post,QOL,survivor,ship,Finally,field,hematology,general,particular,suffers,from,paucity,follow,ups,are,crucial,regarding,related,toxicities,including,example,secondary,malignancies
AB值：
0.503205
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
