典型文献
The epigenetic mechanisms underlying gamete origin of adult-onset diseases
文献摘要：
The events occurring before and soon after birth appear to impact an individual's health throughout adulthood significantly.The pioneering work of David J.P.Barker studied the nutritional status of 2414 pregnant women and their offspring during the Dutch famine between 1944 and 1945,and convincingly connected undernutrition during pregnancy to the predisposition of offspring to many adult-onset diseases,including cardiovascular disease,aberrant glucose metabolism,hypertension,central obesity,and dyslipidemia.This not only attracted global attention but also con-tributed to the genesis of the term"developmental origins of health and disease"(DOHaD),which emphasizes the contribution of prenatal and perinatal exposure to adverse environments to the etiology of diseases in later childhood and adult life[1].A large number of subsequent clinical epidemiology and animal studies proved that both fetal exposure and infant growth patterns can sig-nificantly affect the occurrence of adult-onset diseases.Given that the phenotypic transmission is often limited to one generation and the phenotypic distribution does not follow Mendel's laws,the underlying mechanism(s)has/have been hypothesized to be epige-netic rather than genetic.
文献关键词：
中图分类号：
作者姓名：
Guolian Ding;Bin Chen;John R.McCarrey;Hefeng Huang
作者机构：
Obstetrics and Gynecology Hospital,Institute of Reproduction and Development,Fudan University,Shanghai 200011,China;Research Units of Embryo Original Diseases,Chinese Academy of Medical Sciences,Shanghai 200030,China;Key Laboratory of Reproductive Genetics(Ministry of Education),Department of Reproductive Endocrinology,Women's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Assisted Reproduction Unit,Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province,Hangzhou 310016,China;Department of Neuroscience,Developmental and Regenerative Biology,University of Texas at San Antonio,San Antonio 78249,USA;Shanghai Key Laboratory of Embryo Original Diseases,Shanghai 200030,China
文献出处：
引用格式：
[1]Guolian Ding;Bin Chen;John R.McCarrey;Hefeng Huang-.The epigenetic mechanisms underlying gamete origin of adult-onset diseases)[J].科学通报（英文版）,2022(17):1724-1727
A类：
undernutrition,Mendel,epige
B类：
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AB值：
0.662074
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