典型文献
Energy landscape decomposition for cell differentiation with proliferation effect
文献摘要：
Complex interactions between genes determine the development and differentiation of cells.We establish a landscape theory for cell differentiation with proliferation effect,in which the developmental process is modeled as a stochastic dynamical system with a birth-death term.We find that two different energy landscapes,denoted U and V,collectively contribute to the establishment of non-equilibrium steady differentiation.The potential U is known as the energy landscape leading to the steady distribution,whose metastable states stand for cell types,while V indicates the differentiation direction from pluripotent to differentiated cells.This interpretation of cell differentiation is different from the previous landscape theory without the proliferation effect.We propose feasible numerical methods and a mean-field approximation for constructing landscapes U and V.Successful applications to typical biological models demonstrate the energy landscape decomposition's validity and reveal biological insights into the considered processes.
文献关键词：
中图分类号：
作者姓名：
Jifan Shi;Kazuyuki Aihara;Tiejun Li;Luonan Chen
作者机构：
Research Institute of Intelligent Complex Systems,Fudan University,Shanghai 200433,China;International Research Center for Neurointelligence,The University of Tokyo Institutes for Advanced Study,The University of Tokyo,Tokyo 113-0033,Japan;Key Laboratory of Mathematics and Its Applications(LMAM)and School of Mathematical Sciences,Peking University,Beijing 100871,China;Key Laboratory of Systems Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China;Key Laboratory of Systems Health Science of Zhejiang Province,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;Guangdong Institute of Intelligence Science and Technology,Zhuhai 519031,China
文献出处：
引用格式：
[1]Jifan Shi;Kazuyuki Aihara;Tiejun Li;Luonan Chen-.Energy landscape decomposition for cell differentiation with proliferation effect)[J].国家科学评论（英文版）,2022(08):135-143
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B类：
Energy,decomposition,differentiation,proliferation,effect,Complex,interactions,between,genes,determine,cells,We,theory,which,developmental,modeled,stochastic,dynamical,system,birth,death,find,that,two,energy,landscapes,denoted,collectively,contribute,establishment,equilibrium,steady,potential,known,leading,distribution,whose,metastable,states,stand,types,while,indicates,direction,from,pluripotent,differentiated,This,interpretation,previous,without,propose,feasible,numerical,methods,mean,field,approximation,constructing,Successful,applications,typical,biological,models,demonstrate,validity,reveal,insights,into,considered,processes
AB值：
0.579658
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