Purpose:Onset-based differences are understudied in Auditory Neuropathy Spectrum Disorder(ANSD)in dimensions such as voice,which is addressed in the study.The study aimed to profile and predict the best metrics of onset-related differences in acoustic vocal characteristics of early and late-onset ANSD patients.Methods:31 participants(15 early and 16 late-onset)aged 15-30 years diagnosed with ANSD were included in the study.The sustained phonation of vowel/i/recorded by the participants using android based smartphones of selected configuration was sent over email to the experimenter.Acoustic pa-rameters(fundamental frequency,harmonic frequencies,jitter,shimmer,harmonic-to-noise ratio,cepstral peak prominence-CPP,and pitch sigma)were analysed using Praat software.Results:Results revealed significantly increased(p＜0.05)fundamental frequency along with decreased F2 and F3 of/i/in the early-onset ANSD compared to the late-onset group,which can be explained based on differences in the pathophysiology of the disorder.Although not statistically significant,mean per-turbations(jitter and shimmer),harmonic-to-noise ratio,cepstral peak prominence,and pitch sigma were more affected in the early-onset group,reflective of lowered auditory feedback and periodicity in their voice samples.Results of discriminant analysis marked the emergence of F2,F3,and CPP as the most sensitive metrics for onset-based group differences in voice characteristics.Conclusions:The findings from the study highlight the role of acoustical voice evaluation(especially CPP,F2&F3)in verifying the onset of ANSD disorder.The insights from the onset-based differences seen in vocal characteristics can indirectly help audiologists in deciding the management options for ANSD.

Prateek Lokwani;Prashanth Prabhu;Kavassery Venkateswaran Nisha

Department of Audiology,All India Institute of Speech and Hearing,Manasagangothri,Mysuru,570 006,India

中华耳科学杂志（英文版）

[1]Prateek Lokwani;Prashanth Prabhu;Kavassery Venkateswaran Nisha-.Profiles and predictors of onset based differences in vocal characteristics of adults with auditory neuropathy spectrum disorder(ANSD))[J].中华耳科学杂志（英文版）,2022(04):218-225

ANSD,experimenter,acoustical,audiologists

Profiles,predictors,onset,differences,vocal,characteristics,adults,auditory,neuropathy,spectrum,disorder,Purpose,Onset,understudied,Auditory,Neuropathy,Spectrum,Disorder,dimensions,such,voice,which,addressed,study,aimed,profile,best,metrics,related,early,patients,Methods,participants,aged,years,diagnosed,included,sustained,phonation,vowel,recorded,by,using,android,smartphones,selected,configuration,was,sent,over,email,Acoustic,rameters,fundamental,frequency,harmonic,frequencies,jitter,shimmer,noise,cepstral,peak,prominence,CPP,pitch,sigma,analysed,Praat,software,Results,revealed,significantly,increased,along,decreased,F2,F3,compared,group,explained,pathophysiology,Although,not,statistically,mean,turbations,more,affected,reflective,lowered,feedback,periodicity,their,samples,discriminant,analysis,marked,emergence,most,sensitive,Conclusions,findings,from,highlight,role,evaluation,especially,verifying,insights,seen,indirectly,help,deciding,management,options

0.497061