典型文献
Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs
文献摘要：
After decades of development,protein and peptide drugs have now grown into a major drug class in the marketplace.Target identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target selection.However,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are lacking.Here,we systematically explore the target spaces in the human genome specifically for protein and peptide drugs.Compared with other proteins,both suc-cessful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many aspects.Based on these features,we develop separate effective genome-wide target prediction models for protein and peptide drugs.Finally,a user-friendly web server,Predictor Of Protein and Peptide drugs'therapeutic Targets(POPPIT)(),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets.
文献关键词：
中图分类号：
作者姓名：
Zhongyang Liu;Honglei Li;Zhaoyu Jin;Yang Li;Feifei Guo;Yangzhige He;Xinyue Liu;Yaning Qi;Liying Yuan;Fuchu He;Dong Li
作者机构：
State Key Laboratory of Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,Beijing 102206,China;School of Basic Medical Sciences,Anhui Medical University,Hefei 230032,China;College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China;Suzhou Geneworks Technology Co.,Ltd.,Suzhou 215028,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Department of Medical Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100730,China;College of Life Sciences,Hebei University,Baoding 071002,China;College of Life Sciences,Nankai University,Tianjin 300071,China
文献出处：
引用格式：
[1]Zhongyang Liu;Honglei Li;Zhaoyu Jin;Yang Li;Feifei Guo;Yangzhige He;Xinyue Liu;Yaning Qi;Liying Yuan;Fuchu He;Dong Li-.Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs)[J].基因组蛋白质组与生物信息学报（英文版）,2022(04):780-794
A类：
POPPIT
B类：
Exploration,Spaces,Human,Genome,Protein,Peptide,Drugs,After,decades,peptide,drugs,have,grown,into,major,class,marketplace,identification,validation,crucial,discovery,bioinformatics,prediction,targets,characteristics,known,proteins,will,help,improve,efficiency,success,selection,However,owing,developmental,history,pharmaceutical,industry,previous,exploration,spaces,has,mainly,focused,traditional,small,molecule,while,studies,related,lacking,Here,systematically,explore,human,genome,specifically,Compared,other,both,cessful,many,special,also,significantly,different,from,those,aspects,Based,these,features,separate,effective,wide,models,Finally,user,friendly,web,server,Predictor,Of,therapeutic,Targets,established,which,provides,only,but,abundant,annotations,predicted
AB值：
0.548416
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
