典型文献
The Rational Combination Strategy of Immunomodulatory Latency Reversing Agents and Novel Immunotherapy to Achieve HIV-1 Cure
文献摘要：
Human immunodeficiency virus (HIV)-1 infection creates a persistent latent reservoir even after antiretroviral therapy, which is the main barrier to HIV cure. One of the most explored strategies is the use of latent reversal agents (LRAs) to activate HIV latent reservoirs, followed by immunotherapy to remove infected cells. Immunomodulatory LRAs have the dual advantage of activating viral latency and promoting immune cell elimination of HIV-infected cells. The emergence of novel immunotherapies has also enhanced the possibility of HIV clearance. Here we review the activity and potential mechanisms of immunomodulatory agonists and immunotherapies. The possible combinational strategies to achieve HIV functional cure and the problems encountered using this approach are discussed.
文献关键词：
HIV-1;Combination strategy;Immunomodulator latency reversing agents;Immunotherapy;Shock and kill
中图分类号：
作者姓名：
Li Yangyang;Hong Junxian;Zhang Linqi
作者机构：
NexVac Research Center, Comprehensive AIDS Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;Joint Graduate Program of Peking-Tsinghua-NIBS, School of Life Sciences, Tsinghua University, Beijing 100084, China
文献出处：
引用格式：
[1]Li Yangyang;Hong Junxian;Zhang Linqi-.The Rational Combination Strategy of Immunomodulatory Latency Reversing Agents and Novel Immunotherapy to Achieve HIV-1 Cure)[J].感染性疾病和免疫（英文）,2022(04):263-273
A类：
LRAs,Immunomodulator
B类：
Rational,Combination,Strategy,Immunomodulatory,Latency,Reversing,Agents,Novel,Immunotherapy,Achieve,HIV,Cure,Human,immunodeficiency,virus,infection,creates,persistent,latent,even,after,antiretroviral,which,main,barrier,cure,One,most,explored,strategies,use,reversal,agents,activate,reservoirs,followed,by,immunotherapy,remove,infected,cells,have,dual,advantage,activating,latency,promoting,immune,elimination,emergence,novel,immunotherapies,has,also,enhanced,possibility,clearance,Here,review,activity,potential,mechanisms,immunomodulatory,agonists,possible,combinational,achieve,functional,problems,encountered,using,this,approach,are,discussed,strategy,reversing,Shock,kill
AB值：
0.65824
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
