典型文献
The imbalance of T-cell immunoglobulin and ITIM domain and CD226 on regulatory T cell in recurrent spontaneous abortion patients
文献摘要：
Objective::To analyze the proportion of peripheral regulatory T cells (Tregs) and the expression of the immune checkpoint molecules T-cell immunoglobulin and ITIM domain (TIGIT) and CD226 on Tregs in patients with recurrent spontaneous abortion (RSA).Methods::The proportion of CD3
+CD4
+CD25
+Foxp3
+ Tregs and the expression levels of CD226 and TIGIT on Tregs in 30 normal pregnant women and 28 patients with RSA were determined via flow cytometry.
Results::The proportion of Tregs in the RSA group (4.41 % ± 1.54%) was significantly lower than that in the control group (5.27% ± 1.52%,
P = 0.0374). Compared with the normal pregnant women, patients with RSA showed decreased TIGIT expression (54.75 ± 9.70%
vs. 63.07 ± 12.48%,
P = 0.0066) and increased CD226 expression on Tregs (25.59% ± 8.22%
vs. 20.46% ± 6.97%,
P = 0.0168). The ratio of CD226 to TIGIT in the RSA group (0.48 ± 0.19) was higher than that in the control group (0.34 ± 0.15,
P = 0.0027). The proportion of TIGIT
+CD226
+ Tregs was significantly lower in patients with RSA (9.30% ± 4.95%
vs. 13.43% ± 4.72%,
P = 0.0020) than in the controls.
Conclusions::Patients with RSA show a reduced proportion of Tregs and an imbalance in the expression of TIGIT and CD226 on Tregs.
文献关键词：
Recurrent spontaneous abortion;TIGIT;CD226
中图分类号：
作者姓名：
Li Cui;Ying Chun-Mei;Duan Zhong-Liang
作者机构：
Department of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
文献出处：
引用格式：
[1]Li Cui;Ying Chun-Mei;Duan Zhong-Liang-.The imbalance of T-cell immunoglobulin and ITIM domain and CD226 on regulatory T cell in recurrent spontaneous abortion patients)[J].生殖与发育医学（英文）,2022(03):175-180
A类：
TIGIT
,+CD226
B类：
imbalance,immunoglobulin,ITIM,domain,regulatory,recurrent,spontaneous,abortion,patients,Objective,To,analyze,proportion,peripheral,cells,Tregs,expression,immune,checkpoint,molecules,RSA,Methods,CD3
,+CD4
,+CD25
,+Foxp3
,levels,normal,pregnant,women,were,determined,via,flow,cytometry,Results,group,was,significantly,lower,than,that,Compared,showed,decreased,increased,ratio,higher,controls,Conclusions,Patients,reduced,Recurrent
AB值：
0.331061
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