典型文献
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats
文献摘要：
Objective: To explore the effects of a nano-formulation of curcumin (phytosomal curcumin) on the clinical and pathological symptoms of collagen-induced arthritis (CIA) in rats. Methods: Forty male Wistar rats were immunized with an emulsion containing bovine type Ⅱ collagen and incomplete Freund's adjuvant and then administered phytosomal curcumin post-immunization. Clinical symptoms and histological analysis of the synovial tissues were performed. The effect of phytosomal curcumin on Th17 and Treg parameters was also evaluated. Results: Phytosomal curcumin reduced the clinical severity and paw swelling in CIA-induced rats, which was accompanied by a reduction in the number of inflammatory cell infiltration in the synovial tissue. Additionally, treatment with phytosomal curcumin significantly inhibited CIA-associated mediators as well as increased the anti-inflammatory mediators in comparison to the control groups. Conclusions: Phytosomal curcumin could improve CIA autoimmune responses and can be considered a potential candidate for the treatment of rheumatoid arthritis.
文献关键词：
中图分类号：
作者姓名：
Mahnaz Ramezani;Nahid Zainodini;Reza Nosratabadi;Yaser Yousefpoor;Zahra Taghipour;Mitra Abbasifard;Mohammad Reza Rahmani
作者机构：
Immunology of Infectious Diseases Research Center,Research Institute of Basic Medical Sciences,Rafsanjan University of Medical Sciences,Rafsanjan,Iran;Department of Medical Immunology,Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran;Gastroenterology and Hepathology Research Center,Institute of Basic and Clinical Physiology Sciences,Kerman University of Medical Sciences,Kerman,Iran;Department of Medical Biotechnology,School of Paramedical Sciences,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran;Khalil Abad Health Center,Mashhad University of Medical Sciences,Mashhad,Iran;Department of Anatomy,School of Medicine,Rafsanjan University of Medical Sciences,Rafsanjan,Iran;Physiology-Pharmacology Research Center,Research Institute of Basic Medical Sciences,Rafsanjan University of Medical Sciences,Rafsanjan,Iran;Department of Internal Medicine,Ali-Ibn Abi-Talib Hospital,School of Medicine,Rafsanjan University of Medical Sciences,Rafsanjan,Iran;Department of Physiology and Pharmacology,School of Medicine,Rafsanjan University of Medical Sciences,Rafsanjan,Iran
文献出处：
引用格式：
[1]Mahnaz Ramezani;Nahid Zainodini;Reza Nosratabadi;Yaser Yousefpoor;Zahra Taghipour;Mitra Abbasifard;Mohammad Reza Rahmani-.Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats)[J].亚太热带生物医学杂志（英文版）,2022(11):466-474
A类：
Phytosomal,phytosomal
B类：
curcumin,alleviates,collagen,induced,arthritis,by,downregulating,Th17,upregulating,Treg,cell,responses,rats,Objective,To,explore,effects,nano,formulation,clinical,pathological,symptoms,CIA,Methods,Forty,male,Wistar,were,immunized,emulsion,containing,bovine,type,incomplete,Freund,adjuvant,then,administered,post,immunization,Clinical,histological,analysis,synovial,tissues,performed,parameters,was,also,evaluated,Results,reduced,severity,paw,swelling,which,accompanied,reduction,number,inflammatory,infiltration,Additionally,treatment,significantly,inhibited,associated,mediators,increased,anti,comparison,control,groups,Conclusions,could,improve,autoimmune,considered,potential,candidate,rheumatoid
AB值：
0.532345
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