典型文献
Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats
文献摘要：
Objective: To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide (LPS) induced inflammation and oxidative damage in hepatic and renal tissues of rats.Methods: The rats were divided into four groups: control, LPS, LPS+Boswellia serrata extracts (100 mg/kg and 200 mg/kg). LPS (1 mg/kg) and the extract (100 and 200 mg/kg, 30 min before LPS) were administered intraperitoneally for 3 weeks. The levels of liver enzymes, albumin, total protein, creatinine, blood urea nitrogen (BUN), interleukin (IL)-6, malondialdehyde (MDA), and total thiol groups and superoxide dismutase (SOD) and catalase (CAT) activities were measured. Results: The levels of liver enzymes, creatinine, and BUN, IL-6, MDA in the LPS group were markedly increased (P<0.001) while albumin, total protein, and total thiol concentration, as well as SOD and CAT activities, were decreased compared with the control group (P<0.05 or 0.01). Boswellia serrata extracts diminished the levels of liver enzymes, creatinine, BUN, IL-6, and MDA (P<0.01 and P<0.001), and elevated the concentration of total protein and total thiol and SOD and CAT activities (P<0.05 or 0.01). Conclusions: The ethyl acetate gum resin extract of Boswellia serrata reduces LPS-induced inflammatory reactions and oxidative damage, thus ameliorating hepatic and renal function.
文献关键词：
中图分类号：
作者姓名：
Narges Marefati;Farimah Beheshti;Poorya Etemadizadeh;Mahmoud Hosseini;Akbar Anaeigoudari
作者机构：
Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran;Neuroscience Research Center,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran;Department of Physiology,School of Paramedical Sciences,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran;Division of Neurocognitive Sciences,Psychiatry and Behavioral Sciences Research Center,Mashhad University of Medical Sciences,Mashhad,Iran;Department of Physiology,School of Medicine,Jiroft University of Medical Sciences,Jiroft,Iran
文献出处：
引用格式：
[1]Narges Marefati;Farimah Beheshti;Poorya Etemadizadeh;Mahmoud Hosseini;Akbar Anaeigoudari-.Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats)[J].亚太热带生物医学杂志（英文版）,2022(01):20-25
A类：
Boswellia,LPS+Boswellia
B类：
Gum,resin,serrata,attenuates,lipopolysaccharide,induced,inflammation,oxidative,damage,hepatic,renal,tissues,rats,Objective,To,explore,effect,ethyl,acetate,gum,Methods,were,divided,into,four,groups,control,extracts,before,administered,intraperitoneally,weeks,levels,liver,enzymes,albumin,total,protein,creatinine,blood,urea,nitrogen,BUN,interleukin,malondialdehyde,thiol,superoxide,dismutase,catalase,CAT,activities,measured,Results,markedly,increased,while,concentration,decreased,compared,diminished,elevated,Conclusions,reduces,inflammatory,reactions,thus,ameliorating,function
AB值：
0.397965
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