典型文献
A pilot prospective prevalence study of chronic rhinosinusitis associated with inflammatory bowel disease
文献摘要：
Background::Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. Extra-intestinal manifestations such as pulmonary diseases have been reported. Chronic rhinosinusitis (CRS), an inflammatory condition of the sinonasal mucosa, has been associated with several lung diseases. Given the relationship between lung and intestinal pathologies, and lung and sinus pathologies, we aimed to determine the prevalence of IBD among CRS patients.Methods::Pilot prevalence study. Ninety-two CRS patients were screened for IBD symptoms from October 2018 to January 2020. Patient-reported disease symptoms and overall quality of life were evaluated using the Sino-Nasal Outcome Test 22 (SNOT-22), Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and EuroQol 5 Dimension 5 Level (EQ-5D-5L) questionnaires. The Modified Lund–Kennedy (MLK) endoscopic and Lund–Mackay (LM) grading systems were used to confirm CRS diagnoses. Individuals who reported subjective symptoms of IBD were referred to a gastroenterologist clinic for further diagnostics.Results::Twenty of the 92 (20.2%, 95% CI: 12.6%–29.8%) CRS patients reported symptoms of IBD and four individuals (4.26%, 95% CI: 1.17%–10.50%) were sub-sequently diagnosed with IBD. Compared to patients without IBD symptoms (
n= 72), those with symptoms (
n= 20) reported significantly worse SNOT-22 (
P = 0.002), SIBDQ (
P < 0.05), and EQ-5D-3L (
P = 0.0063) scores. However, these patients did not exhibit significantly different MLK (
P= 0.81) or LM (
P= 0.04) scores.
Conclusion::The prevalence of IBD may be elevated among individuals with CRS relative to the general Canadian population. This pilot study suggests that CRS with IBD is associated with lower quality of life. Further cross-sectional studies with larger sample sizes are required.
文献关键词：
chronic rhinosinusitis;microbiome;Modified Lund–Kennedy;quality of life;Sino-Nasal Outcome Test 22 (SNOT-22)
中图分类号：
作者姓名：
Dhillon India;Ham Jennifer;Maul Ximena;Rosenfeld Gregory;Thamboo Andrew
作者机构：
Division of Otolaryngology, St. Paul's Sinus Centre, University of British Columbia, Vancouver, British Columbia, Canada;Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
文献出处：
引用格式：
[1]Dhillon India;Ham Jennifer;Maul Ximena;Rosenfeld Gregory;Thamboo Andrew-.A pilot prospective prevalence study of chronic rhinosinusitis associated with inflammatory bowel disease)[J].世界耳鼻咽喉头颈外科杂志（英文）,2022(04):339-344
A类：
SIBDQ,MLK,gastroenterologist
B类：
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AB值：
0.540542
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