典型文献
The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans
文献摘要：
Dietary restriction usually suppresses biosynthesis but activates catabolic pathways in animals.However,the short-term starvation enhances biosynthetic activities and promotes ribosomal biogenesis in adult Caenorhabditis elegans.The mechanism underlying the processes remains largely unknown.Here,we find that the short-term starvation enhances the SL1 trans-splicing of translation-related genes in adult C.elegans by transcriptome analysis.The small nuclear RNA-activating protein complex(SNAPc)promotes SL RNA production and mediates starvation-induced trans-splicing.TOFU-5,a core factor in the upstream sequence transcription complex(USTC)essential for piRNA production,is also involved in the starvation-induced trans-splicing processes.Knocking down components of the SNAPc complex and tofu-5 extends worm survival under starvation conditions.Taken together,our study highlights the importance of SL trans-splicing in the nutrition response and reveals a mechanism of the survival regulation by food deprivation via SNAPc and TOFU-5.
文献关键词：
中图分类号：
作者姓名：
Xinhao Hou;Chengming Zhu;Mingjing Xu;Xiangyang Chen;Cheng Sun;Bj?rn Nashan;Shouhong Guang;Xuezhu Feng
作者机构：
The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,School of Life Sciences,Ministry of Education Key Laboratory for Membraneless Organelles & Cellular Dynamics,The USTC RNA Institute,Department of Obstetrics and Gynecology,Biomedical Sciences and Health Laboratory of Anhui Province,University of Science and Technology of China,Hefei,Anhui 230001,China;CAS Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Hefei,Anhui 230027,China
文献出处：
引用格式：
[1]Xinhao Hou;Chengming Zhu;Mingjing Xu;Xiangyang Chen;Cheng Sun;Bj?rn Nashan;Shouhong Guang;Xuezhu Feng-.The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans)[J].遗传学报,2022(10):952-964
A类：
SNAPc,TOFU,tofu
B类：
complex,mediates,starvation,induced,splicing,Caenorhabditis,elegans,Dietary,restriction,usually,suppresses,biosynthesis,but,activates,catabolic,pathways,animals,However,short,term,enhances,biosynthetic,activities,promotes,ribosomal,biogenesis,adult,mechanism,underlying,processes,remains,largely,unknown,Here,find,that,SL1,translation,related,by,transcriptome,analysis,small,nuclear,activating,protein,production,core,upstream,sequence,transcription,USTC,essential,piRNA,also,involved,Knocking,down,components,extends,worm,survival,conditions,Taken,together,our,study,highlights,importance,nutrition,response,reveals,regulation,food,deprivation,via
AB值：
0.532754
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
