典型文献
The chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in ArabidopsisFA
文献摘要：
Plasticity in root system architecture (RSA) allows plants to adapt to changing nutritional status in the soil. Phosphorus availability is a major deter-minant of crop yield, and RSA remodeling is crit-ical to increasing the efficiency of phosphorus acquisition. Although substantial progress has been made in understanding the signaling mech-anism driving phosphate starvation responses in plants, whether and how epigenetic regulatory mechanisms contribute is poorly understood. Here, we report that the Switch defective/sucrose non-fermentable (SWI/SNF) ATPase BRAHMA (BRM) is involved in the local response to phos-phate (Pi) starvation. The loss of BRM function induces iron (Fe) accumulation through increased LOW PHOSPHATE ROOT1 (LPR1) and LPR2 ex-pression, reducing primary root length under Pi deficiency. We also demonstrate that BRM re-cruits the histone deacetylase (HDA) complex HDA6-HDC1 to facilitate histone H3 deacetylation at LPR loci, thereby negatively regulating local Pi deficiency responses. BRM is degraded under Pi deficiency conditions through the 26 S protea-some pathway, leading to increased histone H3 acetylation at the LPR loci. Collectively, our data suggest that the chromatin remodeler BRM, in concert with HDA6, negatively regulates Fe-dependent local Pi starvation responses by transcriptionally repressing the RSA-related genes LPR1 and LPR2 in Arabidopsis thaliana.
文献关键词：
中图分类号：
作者姓名：
Tao Li;Ruyue Zhang;Viswanathan Satheesh;Peng Wang;Guojie Ma;Jianfei Guo;Guo-Yong An;Mingguang Lei
作者机构：
Shanghai Center for Plant Stress Biology,CAS Center for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences,Shanghai 201602,China;University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Crop Stress Adaptation and Improvement,School of Life Sciences,Henan University,Kaifeng 475004,China
文献出处：
引用格式：
[1]Tao Li;Ruyue Zhang;Viswanathan Satheesh;Peng Wang;Guojie Ma;Jianfei Guo;Guo-Yong An;Mingguang Lei-.The chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in ArabidopsisFA)[J].植物学报（英文版）,2022(12):2314-2326
A类：
remodeler,BRAHMA,HISTONE,DEACETYLASE6,ArabidopsisFA,minant,PHOSPHATE,ROOT1,LPR1,LPR2,cruits,HDA6,HDC1,protea
B类：
chromatin,recruits,root,growth,inhibition,phosphate,starvation,Plasticity,system,architecture,RSA,allows,plants,adapt,changing,nutritional,status,soil,Phosphorus,availability,major,deter,crop,yield,remodeling,crit,ical,increasing,efficiency,phosphorus,acquisition,Although,substantial,progress,has,been,made,understanding,signaling,driving,responses,whether,how,epigenetic,regulatory,mechanisms,contribute,poorly,understood,Here,we,report,that,Switch,defective,sucrose,fermentable,SWI,SNF,ATPase,BRM,involved,local,Pi,loss,function,induces,iron,accumulation,through,increased,LOW,pression,reducing,primary,length,deficiency,We,also,demonstrate,histone,deacetylase,complex,facilitate,H3,deacetylation,loci,thereby,negatively,regulating,degraded,conditions,some,pathway,leading,Collectively,our,data,suggest,concert,regulates,dependent,transcriptionally,repressing,related,genes,thaliana
AB值：
0.488397
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