典型文献
Emerging roles of spliceosome in cancer and immunity
文献摘要：
Precursor messenger RNA(pre-mRNA)splicing is cat-alyzed by an intricate ribonucleoprotein complex called the spliceosome.Although the spliceosome is consid-ered to be general cell"housekeeping"machinery,mutations in core components of the spliceosome fre-quently correlate with cell-or tissue-specific pheno-types and diseases.In this review,we expound the links between spliceosome mutations,aberrant splicing,and human cancers.Remarkably,spliceosome-targeted therapies(STTs)have become efficient anti-cancer strategies for cancer patients with splicing defects.We also highlight the links between spliceosome and immune signaling.Recent studies have shown that some spliceosome gene mutations can result in immune dysregulation and notable phenotypes due to mis-splicing of immune-related genes.Furthermore,several core spliceosome components harbor splicing-inde-pendent immune functions within the cell,expanding the functional repertoire of these diverse proteins.
文献关键词：
中图分类号：
作者姓名：
Hui Yang;Bruce Beutler;Duanwu Zhang
作者机构：
Department of Neurosurgery,Huashan Hospital,Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration,MOE Frontiers Center for Brain Science,Institute for Translational Brain Research,Shanghai Medical College,Fudan University,Shanghai 200032,China;Center for the Genetics of Host Defense,University of Texas Southwestern Medical Center,Dallas,TX 75390,USA;Children's Hospital of Fudan University,and Shanghai Key Laboratory of Medical Epigenetics,International Co-laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China
文献出处：
引用格式：
[1]Hui Yang;Bruce Beutler;Duanwu Zhang-.Emerging roles of spliceosome in cancer and immunity)[J].蛋白质与细胞,2022(08):559-579
A类：
STTs
B类：
Emerging,roles,spliceosome,immunity,Precursor,messenger,pre,splicing,alyzed,by,intricate,ribonucleoprotein,complex,called,Although,consid,ered,general,cell,housekeeping,machinery,mutations,core,components,fre,quently,correlate,tissue,specific,diseases,In,this,review,expound,links,between,aberrant,human,cancers,Remarkably,targeted,therapies,have,become,efficient,anti,strategies,patients,defects,We,also,highlight,immune,signaling,Recent,studies,shown,that,result,dysregulation,notable,phenotypes,due,mis,related,genes,Furthermore,several,harbor,inde,pendent,functions,within,expanding,functional,repertoire,these,diverse,proteins
AB值：
0.599391
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