典型文献
Stereodivergent Synthesis of Carbocyclic Quaternary α-Amino Acid Derivatives Containing Two Contiguous Stereocenters
文献摘要：
A novel approach to stereodivergent synthesis of carbocyclic a-quaternary amino acid derivatives,bearing two contiguous stereocen-ters,is proposed through sequential dual Cu/Ir-catalyzed asymmetric allylation and ring-closing metathesis.A variety of five and six-membered carbocyclic α-quaternary amino acid derivatives could be readily achieved in good to high yields with exclusive regiose-lectivities,excellent diastereoselectivities(13∶1-＞20∶1 dr)and enantioselectivities(generally＞99％ee).Of particular note is that the current protocol is also a versatile synthetic tool for the stereodivergent construction of the challenging seven and eight-membered carbocyclic α-amino acid derivatives.All four stereoisomers of these important molecules could be precisely synthesized through the permutation of chiral Cu/Ir catalytic system.The power of this strategy has been demonstrated for the facile access to some biologi-cally active chiral molecules,such as spiro-hydantoins.
文献关键词：
中图分类号：
作者姓名：
Cong Fu;Qi Xiong;Lu Xiao;Ling He;Tian Bai;Zongpeng Zhang;Xiu-Qin Dong;Chun-Jiang Wang
作者机构：
Engineering Research Center of Organosilicon Compounds&Materials,Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 230021,China;Suzhou Institute of Wuhan University,Suzhou,Jiangsu 215123,China
文献出处：
引用格式：
[1]Cong Fu;Qi Xiong;Lu Xiao;Ling He;Tian Bai;Zongpeng Zhang;Xiu-Qin Dong;Chun-Jiang Wang-.Stereodivergent Synthesis of Carbocyclic Quaternary α-Amino Acid Derivatives Containing Two Contiguous Stereocenters)[J].中国化学（英文版）,2022(09):1059-1065
A类：
Stereodivergent,Carbocyclic,Contiguous,Stereocenters,stereodivergent,carbocyclic,stereocen,regiose,lectivities,diastereoselectivities,stereoisomers,hydantoins
B类：
Synthesis,Quaternary,Amino,Acid,Derivatives,Containing,Two,novel,approach,synthesis,quaternary,amino,acid,derivatives,bearing,two,contiguous,proposed,through,sequential,dual,Ir,catalyzed,asymmetric,allylation,closing,metathesis,variety,five,six,membered,could,readily,achieved,good,high,yields,exclusive,excellent,dr,enantioselectivities,generally,Of,particular,note,that,current,protocol,also,versatile,synthetic,tool,construction,challenging,seven,eight,All,four,these,important,molecules,precisely,synthesized,permutation,chiral,catalytic,system,power,this,strategy,has,been,demonstrated,facile,access,biologi,cally,active,such,spiro
AB值：
0.571014
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
