典型文献
Synthesis of Chiral Hydantoins and Thiazolidinediones via Iridium-Catalyzed Asymmetric Hydrogenation
文献摘要：
Herein,we report an iridium-catalyzed asymmetric hydrogenation of hydantoin and thiazolidinedione derived exocyclic alkenes using our developed BiphPHOX as a ligand.The transformation shows good functional group tolerance,and gives the hydrogenated prod-ucts with excellent yields(up to 99％)and enantioselectivities(up to 98％ee).A gram-scale reaction was also carried out,and pro-vided the hydrogenated product in excellent yield with no erosion in enantioselectivity.Finally,the transformation of the hydrogen-ated product provided an efficient approach for the synthesis of the intermediate of a HIV protease inhibitor.
文献关键词：
中图分类号：
作者姓名：
Yu Nie;Jing Li;Qianjia Yuan;Wanbin Zhang
作者机构：
Shanghai Key Laboratory of Molecular Engineering of Chiral Drugs,Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,800 Dongchuan Road,Shanghai 200240,China;College of Chemistry,Zhengzhou University,75 Daxue Road,Zhengzhou,Henan 450052,China
文献出处：
引用格式：
[1]Yu Nie;Jing Li;Qianjia Yuan;Wanbin Zhang-.Synthesis of Chiral Hydantoins and Thiazolidinediones via Iridium-Catalyzed Asymmetric Hydrogenation)[J].中国化学（英文版）,2022(07):819-824
A类：
Hydantoins,Thiazolidinediones,hydantoin,thiazolidinedione,exocyclic,BiphPHOX
B类：
Synthesis,Chiral,via,Iridium,Catalyzed,Asymmetric,Hydrogenation,Herein,we,report,iridium,catalyzed,asymmetric,hydrogenation,derived,alkenes,using,our,developed,ligand,transformation,shows,good,functional,group,tolerance,gives,hydrogenated,ucts,excellent,yields,enantioselectivities,ee,gram,scale,reaction,was,also,carried,out,product,no,erosion,enantioselectivity,Finally,provided,efficient,approach,synthesis,intermediate,HIV,protease,inhibitor
AB值：
0.606922
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