典型文献
An Antifouling Photoelectrochemical Ultramicrosensor for Unbiased Single-Cell Analysis
文献摘要：
The nanoelectrode-based electrochemical method has been widely used for single-cell analysis because of the advantages of high spatiotemporal resolution and in-situ detection capability.As an evolutional generation of the electrochemical analysis,photoelec-trochemical(PEC)sensors not only inherit the above-mentioned merits,but also possess a lower background and higher sensitivity,because they can operate under unbiased conditions.Moreover,electrodes are often impaired by nonspecific binding in complex bi-ological environments.Thus,an antifouling PEC ultramicrosensor is developed for unbiased single-cell analysis in this report.The ul-tramicrosensor is fabricated by self-assembling of photoactive material ZnCalnS nanosheets onto the carbon fiber ultramicroelec-trode surface and further dip-coating of a porous antifouling layer of cross-linked bovine serum albumin supported by carbon nano-tubes.Benefiting from the minimal influence of the ultrathin nanosheet on the ultramicroelectrode morphology and the smooth protective interface formed by the antifouling film,the obtained photoelectrode can be readily inserted into a single cell with negli-gible impact on cell viability and shows excellent antifouling performance.The PEC ultramicrosensor achieves selective detection of dopamine(DA)with a low detection limit(3.97 nmol/L)and exhibits good sensing capability for cytosolic DA in single PC12 cells.This exploration provides new opportunities for single-cell analysis.
文献关键词：
中图分类号：
作者姓名：
Linlin Zhu;Lin Zhong;Juan Wang;Ying Tang;Zhihong Liu
作者机构：
College of Chemistry and Chemical Engineering,Hubei University,Wuhan,Hubei 430062,China;College of Chemistry and Molecular Science,Wuhan University,Wuhan,Hubei 430072,China
文献出处：
引用格式：
[1]Linlin Zhu;Lin Zhong;Juan Wang;Ying Tang;Zhihong Liu-.An Antifouling Photoelectrochemical Ultramicrosensor for Unbiased Single-Cell Analysis)[J].中国化学（英文版）,2022(04):500-506
A类：
Ultramicrosensor,Unbiased,nanoelectrode,ultramicrosensor,tramicrosensor,ZnCalnS,ultramicroelec,ultramicroelectrode,negli,gible
B类：
Antifouling,Photoelectrochemical,Single,Cell,Analysis,method,has,been,widely,used,single,analysis,because,advantages,spatiotemporal,resolution,situ,detection,capability,evolutional,generation,PEC,sensors,not,only,inherit,above,mentioned,merits,but,also,possess,lower,background,higher,sensitivity,they,can,operate,under,unbiased,conditions,Moreover,electrodes,are,often,impaired,by,nonspecific,binding,complex,ological,environments,Thus,antifouling,developed,this,report,fabricated,self,assembling,photoactive,material,nanosheets,onto,carbon,fiber,surface,further,dip,coating,porous,layer,cross,linked,bovine,serum,albumin,supported,tubes,Benefiting,from,minimal,influence,ultrathin,morphology,smooth,protective,interface,formed,film,obtained,photoelectrode,readily,inserted,into,impact,viability,shows,excellent,performance,achieves,selective,dopamine,DA,limit,nmol,exhibits,good,sensing,cytosolic,PC12,cells,This,exploration,provides,new,opportunities
AB值：
0.586851
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