典型文献
Xishaglaucumins A-J,New Cembranoids with Anti-Inflamma-tory Activities from the South China Sea Soft Coral Sarcophyton glaucum
文献摘要：
Ten new cembrane-type diterpenoids,namely xishaglaucumins A-J (1-10),along with ten known related ones (11-20),have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China Sea.Their structures were eluci-dated by extensive spectroscopic analysis,quantum mechanical nuclear magnetic resonance (QM-NMR) methods,X-ray diffraction analysis,chemical methods and comparison with the reported data in the literature.The absolute configuration of new compounds 1,5 and known compounds 11,12,16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu Kα (λ =1.5417 (A)).In in vitro bioassay,compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells.
文献关键词：
中图分类号：
作者姓名：
Jin-Feng Li;Yan-Bo Zeng;Wang-Sheng Li;Hui Luo;Hai-Yan Zhang;Yue-Wei Guo
作者机构：
Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,Hainan 571101,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zu Chong Zhi Road,Zhangjiang Hi-Tech Park,Shanghai 201203,China;Ocean College of Hebei Agricultural University,Qinhuangdao,Hebei 066000,China;Key Laboratory of Zhanjiang for Research and Development Marine Microbial Resources in the Beibu Gulf Rim,Marine Biomedical Research Institute,Guangdong Medical University,Zhanjiang,Guangdong 524023,China;Bohai rim Advanced Research Institute for Drug Discovery,Yantai,Shandong 264000,China
文献出处：
引用格式：
[1]Jin-Feng Li;Yan-Bo Zeng;Wang-Sheng Li;Hui Luo;Hai-Yan Zhang;Yue-Wei Guo-.Xishaglaucumins A-J,New Cembranoids with Anti-Inflamma-tory Activities from the South China Sea Soft Coral Sarcophyton glaucum)[J].中国化学（英文版）,2022(01):79-90
A类：
Xishaglaucumins,Cembranoids,Inflamma,Sarcophyton,cembrane,xishaglaucumins
B类：
New,Anti,Activities,from,South,China,Sea,Soft,Coral,Ten,new,type,diterpenoids,namely,along,known,related,ones,have,been,isolated,soft,coral,collected,off,Island,Their,structures,were,eluci,dated,by,extensive,spectroscopic,analysis,quantum,mechanical,nuclear,magnetic,resonance,QM,NMR,methods,ray,diffraction,chemical,comparison,reported,data,literature,absolute,configuration,compounds,determined,either,using,vitro,bioassay,exhibited,inhibitory,effects,lipopolysaccharide,LPS,induced,inflammatory,responses,BV,microglial,cells
AB值：
0.586146
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