典型文献
An ROS-Responsive Antioxidative Macromolecular Prodrug of Caffeate for Uveitis Treatment
文献摘要：
Uveitis is a sophisticated syndrome showing a high relevance with reactive oxygen species(ROS).Herein,an ROS-responsive PEGylated polypeptide based macromolecular prodrug of herbaceous antioxidant ethyl caffeate(EC)is designed via phenylboronic esters with improved solubility for the alleviation of uveitis.The antioxidative 4-hydroxybenzyl alcohol(HBA)and EC can be released from the macromolecular EC prodrug under the stimulation of ROS,which can effectively protect cells against oxidative stress-induced injury in an ROS-depletion way.The antioxidative and protective effects of the macromolecular EC prodrug in vivo are further verified in a uveitis mouse model.Overall,this work not only provides a handy method to synthesize a phenylboronic ester-bearing EC prodrug which is highly sensitive to pathological ROS,but also depicts a promising future to apply macromolecular antioxidative prodrugs in the treatment of uveitis as well as other ROS-related diseases.
文献关键词：
中图分类号：
作者姓名：
Yu-Tong Li;Si-Ting Sheng;Bo Yu;Fan Jia;Kai Wang;Hai-Jie Han;Qiao Jin;You-Xiang Wang;Jian Ji
作者机构：
MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China;Eye Center the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China
文献出处：
引用格式：
[1]Yu-Tong Li;Si-Ting Sheng;Bo Yu;Fan Jia;Kai Wang;Hai-Jie Han;Qiao Jin;You-Xiang Wang;Jian Ji-.An ROS-Responsive Antioxidative Macromolecular Prodrug of Caffeate for Uveitis Treatment)[J].高分子科学（英文版）,2022(09):1101-1109
A类：
Antioxidative,Macromolecular,Prodrug,Caffeate,Uveitis,hydroxybenzyl,handy
B类：
ROS,Responsive,Treatment,sophisticated,syndrome,showing,relevance,reactive,oxygen,species,Herein,responsive,PEGylated,polypeptide,macromolecular,herbaceous,antioxidant,ethyl,caffeate,EC,designed,phenylboronic,esters,improved,solubility,alleviation,uveitis,antioxidative,alcohol,HBA,can,released,from,under,stimulation,which,effectively,cells,against,stress,induced,injury,depletion,way,protective,effects,vivo,are,further,verified,mouse,model,Overall,this,work,not,only,provides,method,synthesize,bearing,highly,sensitive,pathological,but,also,depicts,promising,future,apply,prodrugs,treatment,well,other,related,diseases
AB值：
0.537023
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