典型文献
Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable,safe and efficient vaccine adjuvant
文献摘要：
To increase antibody secretion and dose sparing,squalene-in-water aluminium hydrogel(alum)-stabilised emulsions(ASEs)have been developed,which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses.Nevertheless,the squalene(oil)in previous attempts suffered from limited oxidation resistance,thus,safety and stability were compromised.From a clinical transla-tional perspective,it is imperative to screen the optimal oils for enhanced emulsion adjuvants.Here,because of the varying oleic to linoleic acid ratio,soybean oil,peanut oil,and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emul-sions,which were then screened for their stability and immunogenicity.Additionally,the underlying mechanisms of oil phases and emulsion stability were unravelled,which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets.As a result,compared with squalene-in-water ASEs,soybean-in-water ASEs exhib-ited comparable immune responses and enhanced stability.By optimising the oil phase of the emulsion adjuvants,this work may offer an alternative strategy for safe,stable,and effective emulsion adjuvants.
文献关键词：
中图分类号：
作者姓名：
Lili Yuan;Xiao-Dong Gao;Yufei Xia
作者机构：
Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministry of Education,School of Biotechnology,Jiangnan University,Wuxi 214122,China;State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China;Innovation Academy for Green Manufacture,Chinese Academy of Sciences,Beijing 100190,China
文献出处：
引用格式：
[1]Lili Yuan;Xiao-Dong Gao;Yufei Xia-.Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable,safe and efficient vaccine adjuvant)[J].化学科学与工程前沿,2022(06):973-984
A类：
Optimising,stabilised,ASEs,emul,unravelled
B类：
phases,aluminium,hydrogel,emulsions,stable,efficient,vaccine,To,antibody,secretion,dose,sparing,squalene,water,have,been,developed,which,offer,increased,surface,areas,cellular,interactions,higher,antigen,loading,enhanced,immune,responses,Nevertheless,previous,attempts,suffered,from,limited,oxidation,resistance,thus,safety,stability,were,compromised,From,clinical,transla,perspective,imperative,optimal,oils,adjuvants,Here,because,varying,linoleic,acid,soybean,peanut,olive,utilised,preparation,then,screened,their,immunogenicity,Additionally,underlying,mechanisms,showed,that,oxidative,capabilities,but,reduced,long,term,storage,owing,relatively,low,zeta,potential,prepared,droplets,result,compared,exhib,comparable,By,optimising,this,work,may,alternative,strategy,effective
AB值：
0.47454
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