典型文献
Short-term inhalation exposure evaluations of airborne antibiotic resistance genes in environments
文献摘要：
Antibiotic resistance is a sword of Damocles that hangs over humans.In regards to airborne antibiotic resistance genes(AARGs),critical knowledge gaps still exist in the identification of hotspots and quantification of exposure levels in different environments.Here,we have studied the profiles of AARGs,mobile genetic elements(MGEs)and bacterial communities in various atmospheric environments by high throughput qPCR and 16S rRNA gene sequenc-ing.We propose a new AARGs exposure dose calculation that uses short-term inhalation(STI).Swine farms and hospitals were high-risk areas where AARGs standardised abundance was more abundant than suburbs and urban areas.Additionally,resistance gene abundance in swine farm worker sputum was higher than that in healthy individuals in other environ-ments.The correlation between AARGs with MGEs and bacteria was strong in suburbs but weak in livestock farms and hospitals.STI exposure analysis revealed that occupational in-take of AARGs(via PM10)in swine farms and hospitals were 110 and 29 times higher than in suburbs,were 1.5×104,5.6×104 and 5.1×102 copies,i.e.,61.9％,75.1％and 10.7％of the overall daily inhalation intake,respectively.Our study comprehensively compares envi-ronmental differences in AARGs to identify high-risk areas,and forwardly proposes the STI exposure dose of AARGs to guide risk assessment.
文献关键词：
中图分类号：
作者姓名：
Zhenchao Zhou;Xinyi Shuai;Zejun Lin;Lingxuan Meng;Xiaoliang Ba;Mark A.Holmes;Hong Chen
作者机构：
Institute of Environmental Technology,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China;Department of Veterinary Medicine,University of Cambridge,Cambridge CB3 9DA,UK
文献出处：
引用格式：
[1]Zhenchao Zhou;Xinyi Shuai;Zejun Lin;Lingxuan Meng;Xiaoliang Ba;Mark A.Holmes;Hong Chen-.Short-term inhalation exposure evaluations of airborne antibiotic resistance genes in environments)[J].环境科学学报（英文版）,2022(12):62-71
A类：
hangs,AARGs,forwardly
B类：
Short,term,inhalation,exposure,evaluations,airborne,antibiotic,resistance,genes,environments,Antibiotic,sword,Damocles,that,humans,In,regards,critical,knowledge,gaps,still,exist,identification,hotspots,quantification,levels,different,Here,have,studied,profiles,mobile,genetic,elements,MGEs,bacterial,communities,various,atmospheric,by,throughput,qPCR,16S,rRNA,sequenc,ing,We,new,dose,calculation,uses,short,STI,Swine,farms,hospitals,were,risk,areas,where,standardised,abundance,was,more,abundant,than,suburbs,urban,Additionally,swine,worker,sputum,higher,healthy,individuals,other,correlation,between,strong,but,weak,livestock,analysis,revealed,occupational,via,PM10,times,copies,overall,daily,intake,respectively,Our,study,comprehensively,compares,ronmental,differences,identify,proposes,guide,assessment
AB值：
0.526686
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