典型文献
Non-targeted metabolomics reveals the stress response of a cellulase-containing penicillium to uranium
文献摘要：
Human industrial activities have caused environmental uranium(U)pollution,resulting in uranium(Ⅵ)had radiotoxicity and chemical toxicity.Here,a cellulase-producing Penicillium fungus was screened and characterized by X-ray fluorescence(XRF),and Fourier transform infrared reflection(FT-IR),as well as by GC/MS metabolomics analysis,to study the response to uranium(Ⅵ)stress.The biomass of Penicillium decreased after exposure to 100 mg/L U.Uranium combined with carboxyl groups,amino groups,and phosphate groups to form ura-nium mineralized deposits on the surface of this fungal strain.The α-activity concentration of uranium in the strain was 2.57×106 Bq/kg,and theβ-activity concentration was 2.27×105 Bq/kg.Metabolomics analysis identified 118 different metabolites,as well as metabolic dis-ruption of organic acids and derivatives.Further analysis showed that uranium significantly affected the metabolism of 9 amino acids in Penicillium.These amino acids were related to the TCA cycle and ABC transporter.At the same time,uranium exhibited nucleotide metabolism toxicity to Penicillium.This study provides an in-depth understanding of the uranium tolerance mechanism of Penicillium and provides a theoretical basis for Penicillium to degrade hyper-enriched plants.
文献关键词：
中图分类号：
作者姓名：
Li Zhang;Jie Li;Jin-long Lai;Xu Yang;Yu Zhang;Xue-gang Luo
作者机构：
School of Life Science and Engineering,Southwest University of Science and Technology,Mianyang 621010,China;Engineering Research Center of Biomass Materials,Ministry of Education of,SWUST,Mianyang 621010,China
文献出处：
引用格式：
[1]Li Zhang;Jie Li;Jin-long Lai;Xu Yang;Yu Zhang;Xue-gang Luo-.Non-targeted metabolomics reveals the stress response of a cellulase-containing penicillium to uranium)[J].环境科学学报（英文版）,2022(10):9-17
A类：
penicillium,radiotoxicity,ruption
B类：
Non,targeted,metabolomics,reveals,stress,response,cellulase,containing,uranium,Human,industrial,activities,have,caused,environmental,pollution,resulting,had,chemical,Here,producing,Penicillium,fungus,was,screened,characterized,by,ray,fluorescence,XRF,Fourier,transform,infrared,reflection,FT,well,analysis,study,biomass,decreased,after,exposure,Uranium,combined,carboxyl,groups,amino,phosphate,mineralized,deposits,surface,this,fungal,strain,activity,concentration,Bq,Metabolomics,identified,different,metabolites,metabolic,dis,organic,acids,derivatives,Further,showed,that,significantly,affected,metabolism,These,were,related,TCA,cycle,ABC,transporter,At,same,exhibited,nucleotide,This,provides,depth,understanding,tolerance,mechanism,theoretical,basis,degrade,hyper,enriched,plants
AB值：
0.551491
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