典型文献
The antiestrogen-like activity and reproductive toxicity of 2,6-DCBQ on female zebrafish upon sub-chronic exposure
文献摘要：
2,6-Dichloro-1,4-benzoquinone(2,6-DCBQ),an emerging water disinfection by-product,is widely detected in water resources.However,its potential effects on the reproductive system are largely unknown.Here,we investigated the long-term effects of 2,6-DCBQon gonadal de-velopment by exposing zebrafish from 15 to 180 days postfertilization(dpf).Following expo-sure to 2,6-DCBQ(20 and 100 μg/L),female-specific effects including delayed puberty onset,retarded ovarian growth and breakdown of the zona radiata were observed,resulting in sub-fertility in adult females.Adverse effects in folliculogenesis disappeared two months after cessation of 2,6-DCBQ administration.In contrast,no adverse impacts were noted in male testes.The effects on females were associated with significant reduction in 17β-estradiol(E2)level,suggesting a role for 2,6-DCBQ in anti-estrogenic activity.E2 level change in blood was further supported by dysregulated expression of genes(cyp19a1a,fshb,kiss3,esr2b,vtg1,and vtg3)related to the hypothalamic-pituitary-gonad-liver(HPGL)axis.The present study demonstrates for the first time that 2,6-DCBQ induces reproductive impairments in female zebrafish through disrupting 17β-estradiol level.
文献关键词：
中图分类号：
作者姓名：
Weeiyi Song;Kun Wu;Xiling Wu;Yichun Lu;Jing Li;Jinhua Li;Mengqiao Cui
作者机构：
Key Laboratory of Human Genetics and Environmental Medicine,School of Public Health,Xuzhou Medical University,Xuzhou 221000,China;State Key Laboratory of Biocontrol,Southern Marine Sciences and Engineering Guangdong Laboratory(Zhuhai),Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering,School of Marine Sciences,Sun Yat-sen University,Guangzhou 510275,China;School of Energy and Environment,City University of Hong Kong,Hong Kong 999077,China;School of Public Health,Jilin University,Changchun 130025,China;Jiangsu Province Key Laboratory of Anesthesiology,Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou Medical University,Xuzhou 221000,China
文献出处：
引用格式：
[1]Weeiyi Song;Kun Wu;Xiling Wu;Yichun Lu;Jing Li;Jinhua Li;Mengqiao Cui-.The antiestrogen-like activity and reproductive toxicity of 2,6-DCBQ on female zebrafish upon sub-chronic exposure)[J].环境科学学报（英文版）,2022(07):10-20
A类：
antiestrogen,DCBQon,postfertilization,folliculogenesis,estrogenic,fshb,kiss3,esr2b,vtg1,vtg3,HPGL
B类：
like,activity,reproductive,toxicity,zebrafish,upon,sub,chronic,exposure,Dichloro,benzoquinone,emerging,water,disinfection,by,widely,detected,resources,However,its,potential,effects,system,largely,unknown,Here,investigated,long,term,gonadal,velopment,exposing,from,days,dpf,Following,specific,including,delayed,puberty,onset,retarded,ovarian,growth,breakdown,zona,radiata,were,observed,resulting,fertility,adult,females,Adverse,disappeared,two,months,after,cessation,administration,In,contrast,adverse,impacts,noted,testes,associated,significant,reduction,estradiol,E2,level,suggesting,role,change,blood,was,further,supported,dysregulated,expression,cyp19a1a,related,hypothalamic,pituitary,liver,axis,present,study,demonstrates,first,that,induces,impairments,through,disrupting
AB值：
0.539735
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