典型文献
Skin Retention Determination and Clinical Efficacy Evaluation of a Novel High Oil-Contained Hpr Transfersome Permeable Formulation
文献摘要：
In order to increase the skin retention of HPR (Hydroxypinacone Retinoate), a novel high oil-contained HPR transfersome WL-HPR1130 was prepared. Conventional essence containing HPR was used as the control group, WL-HPR1130 essence was used as the experimental group, the skin retention of HPR were determined respectively. The anti-wrinkle effcacy of WL-HPR1130 essence was evaluated at the same time. The retention of HPR was 11.40 μg/cm2 in the experimental group and 1.41 μg/cm2 in the control group, which was 8.08 times higher than the control group. The wrinkles and fine lines were significantly reduced and smoothed after 2 and 4 weeks by experimental group sample. The average length, width and depth of wrinkles were decreased by 14.26％, 18.31％ ,7.17％ after 2 weeks, and were decreased by 29.39％, 38.25％ ,8.60％ after 4 weeks. The average length, width and depth of fine lines were decreased by 22.35％, 12.60％, 8.00％ after 2 weeks, and were decreased by 27.10％, 20.24％ and 15.90％ after 4 weeks, which has a significant visual changes. WL-HPR1130, a novel high oil-contained HPR transfersome formulation, can significantly increase the retention of HPR in the skin. And the WL-HPR1130 essence have remarkable anti-wrinkle and smooth fine lines effects.
文献关键词：
中图分类号：
作者姓名：
Wang Jiaqi;Ma Chaolong;Tian Meixiang;Sun Changlei;Gong Jinkang
作者机构：
Shanghai World Leader Pharmaceutical Co.,Ltd.,China
文献出处：
引用格式：
[1]Wang Jiaqi;Ma Chaolong;Tian Meixiang;Sun Changlei;Gong Jinkang-.Skin Retention Determination and Clinical Efficacy Evaluation of a Novel High Oil-Contained Hpr Transfersome Permeable Formulation)[J].日用化学品科学（英文）,2022(04):73-78
A类：
Contained,Hpr,Transfersome,Hydroxypinacone,Retinoate,transfersome,HPR1130,effcacy
B类：
Skin,Retention,Determination,Clinical,Efficacy,Evaluation,Novel,High,Oil,Permeable,Formulation,In,order,increase,skin,retention,novel,oil,contained,WL,was,prepared,Conventional,essence,containing,used,control,group,experimental,were,determined,respectively,anti,evaluated,same,which,times,higher,than,wrinkles,fine,lines,significantly,reduced,smoothed,after,weeks,by,sample,average,length,width,depth,decreased,has,visual,changes,formulation,And,have,remarkable,effects
AB值：
0.33157
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
