典型文献
To unwind the biological knots: The DNA / RNA G- quadruplex resolvase RHAU ( DHX36 ) in development and disease
文献摘要：
The G- quadruplex (G4) sequences are short fragments of 4- interval triple guanine (G) with frequent and ubiquitous distribution in the genome and RNA transcripts. The G4 sequences are usually folded into secondary "knot" structure via Hoogsteen hydrogen bond to exert negative regulation on a variety of biological processes, including DNA replication and transcription, mRNA translation, and telomere maintenance. Recent structural biological and mouse genetics studies have demonstrated that RHAU (DHX36) can bind and unwind the G4 "knots" to modulate embryonic development and postnatal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis, and organ dysfunction. These studies uncovered the pivotal G4 resolvase function of RHAU to release the G4 barrier, which plays fundamental roles in development and physiological homeostasis. This review discusses the latest advancements and findings in deciphering RHAU functions using animal models.
文献关键词：
中图分类号：
作者姓名：
Chensi Yang;Jie Yao;Huijuan Yi;Xinyi Huang;Wukui Zhao;Zhongzhou Yang
作者机构：
State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine , Nanjing University Medical School , Nanjing , China
文献出处：
引用格式：
[1]Chensi Yang;Jie Yao;Huijuan Yi;Xinyi Huang;Wukui Zhao;Zhongzhou Yang-.To unwind the biological knots: The DNA / RNA G- quadruplex resolvase RHAU ( DHX36 ) in development and disease)[J].动物模型与实验医学（英文）,2022(06):542-549
A类：
unwind,resolvase,RHAU,DHX36
B类：
To,biological,knots,quadruplex,development,disease,G4,sequences,are,short,fragments,interval,triple,guanine,frequent,ubiquitous,distribution,genome,transcripts,usually,folded,into,secondary,structure,via,Hoogsteen,hydrogen,bond,exert,negative,regulation,variety,processes,including,replication,transcription,translation,telomere,maintenance,Recent,structural,mouse,genetics,studies,have,demonstrated,that,can,bind,modulate,embryonic,postnatal,Deficiency,gives,rise,lethality,impaired,organogenesis,dysfunction,These,uncovered,pivotal,release,barrier,which,plays,fundamental,roles,physiological,homeostasis,This,review,discusses,latest,advancements,findings,deciphering,functions,using,animal,models
AB值：
0.591197
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