Objective The aim of this study was to evaluate the impact of serum carcinoembryonic antigen (CEA) in the prediction of pathological complete response (pCR) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT). Methods A total of 925 LARC patients who underwent nCRT followed by TME between March 2006 and February 2018 were enrolled at Fudan University Shanghai Cancer Center. Using logistic regression models, we investigated the associations between serum CEA levels and pathological complete remission (pCR). Further stratified analyses were performed according to different CEA thresholds. Results We found that pre-nCRT CEA and post-nCRT CEA were negatively correlated with pCR (P < 0.001). Stratified analyses revealed that when the CEA cutoff value was set to 5 ng/mL, 10.6％ of patients with post-nCRT CEA levels > 5 ng/mL achieved pCR. Meanwhile, when the CEA cutoff value was set to 10 ng/mL, only 6.8％ of the patients with post-nCRT CEA levels > 10 ng/mL achieved pCR. Conclusion In summary, pre- and post-nCRT CEA levels ≤ 5 ng/mL were favorable predictors of pCR in LACR patients, and the "watch and wait" strategy is not recommended for patients with post-nCRT CEA levels > 10 ng/mL.

Lili Shen;Chao Li;Jingwen Wang;Jin Fan;Ji Zhu

Department of Oncology,Nantong Haimen People's Hospital,Haimen Hospital of Nantong University,Nantong 226100,China;Department of Radiotherapy,Huashan Hospital,Fudan University,Shanghai 200032,China;Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,China

肿瘤学与转化医学（英文）

[1]Lili Shen;Chao Li;Jingwen Wang;Jin Fan;Ji Zhu-.CEA levels predict tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer)[J].肿瘤学与转化医学（英文）,2022(04):180-185

LACR

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