典型文献
Is early patent ductus arteriosus ligation helpful in premature neonates?A 10-year retrospective study
文献摘要：
Background To compare short and long outcomes between early(≤28 days)(EL)and late ligation(LL)groups.To explore factors predicting early extubation(≤7 days)after patent ductus arteriosus(PDA)ligation.Methods We conducted a single center,retrospective cohort study of preterm infants＜32 weeks who underwent surgical ligation over a 10-year period(2009-2019).Results A total of 133 infants underwent PDA ligation,in the study period.Both groups had similar short-term outcome such as bronchopulmonary dysplasia(BPD)or death(96％vs.98％,P=0.64)and long-term clinical outcomes including Bayley's assessment at 2 years corrected age.Fewer infants in the EL group developed severe BPD(63％vs.81％,P=0.02).Age at ligation had adjusted odds ratio of 1.04 with over lapping confidence interval(95％CI 1.0-1.1,P=0.02)for severe BPD/death.There was no difference in day of extubation between the EL and LL group(8 days vs.7 days,P=0.85).Left atrium/aortic root ratio of≥1.75 would give sensitivity of 41％and 80％specificity for early extubation(area under the curve of 0.61).There was marginal reduction of hospital stay in the EL group[113(105-121)days vs.115(107-123)days;log rank P=0.026].Conclusion EL can be delivered safely with a clinically important lower incidence of severe BPD and shorter duration of hospital stay compared to LL.
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作者姓名：
Anip Garg;Naveen Athiraman;Elizabeth Jenkins;David Crossland;Prakash Kannan Loganathan
作者机构：
Neonatal Unit,Royal Victoria Infirmary,Newcastle,UK;Paediatric Cardiology,Freeman Hospital,Newcastle,UK;Neonatal Unit,James Cook University Hospital,Marton Road,Middlesbrough TS4 3BW,UK
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引用格式：
[1]Anip Garg;Naveen Athiraman;Elizabeth Jenkins;David Crossland;Prakash Kannan Loganathan-.Is early patent ductus arteriosus ligation helpful in premature neonates?A 10-year retrospective study)[J].世界儿科杂志（英文版）,2022(05):350-357
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0.547864
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