典型文献
Physicians' perspectives on adverse drug reactions in pediatric routine care:a survey
文献摘要：
Background Children and adolescents are at particular risk for adverse drug reactions (ADRs).We investigated physicians' perceptions on ADRs in pediatric routine care.Methods In this exploratory study from April to November 2020,we invited physicians treating pediatric patients across Germany to complete an online questionnaire consisting mainly of closed questions.Results Completion rate was 98％ (127/129).Of all participants,23％ (29/127) stated they were not able to estimate how many of their pediatric patients experienced ADRs during drug therapy.The remaining physicians estimated that 7.5％ (median;Q25/Q753％/20％) of their pediatric patients were affected by ADRs.Regarding counseling on ADRs,61％ (77/127) stated they do not ask regularly the extent to which parents want to be informed.In total,26％ (33/127) stated they avoid coun-seling on ADRs concerning commonly used approved therapies,whereas only 4％ (5/127) did so concerning off-label use(P ＜ 0.001).Altogether,16％ (20/127) stated they rather prescribe new medicines as they hope for better effectiveness;72％(91/127) said they are cautious about doing so owing to yet unknown ADRs.Of all respondents,46％ (58/127) stated they do not report ADRs to the authorities.Concerning the black triangle symbol,a European pharmacovigilance measure,11％(14/127) stated they knew it and 6％ (7/127) stated they reported any suspected ADR for drugs with that symbol.Conclusions Physicians' perspectives on ADRs were ambivalent:ADRs influenced their parent counseling and drug prescrib-ing;yet,they struggled to estimate the impact of ADRs on their patients and were not aware of specific pharmacovigilance measures.
文献关键词：
中图分类号：
作者姓名：
Martina P.Neininger;Sarah Jeschke;Lisa M.Kiesel;Thilo Bertsche;Astrid Bertsche
作者机构：
Clinical Pharmacy,Institute of Pharmacy,Medical Faculty,Leipzig University and Drug Safety Center,Leipzig University and University Hospital,Bruederstrasse 32,04103 Leipzig,Germany;University Hospital for Children and Adolescents,Neuropediatrics,Ernst-Heydemann-Str.8,18057 Rostock,Germany
文献出处：
引用格式：
[1]Martina P.Neininger;Sarah Jeschke;Lisa M.Kiesel;Thilo Bertsche;Astrid Bertsche-.Physicians' perspectives on adverse drug reactions in pediatric routine care:a survey)[J].世界儿科杂志（英文版）,2022(01):50-58
A类：
Q753,seling,prescribe,ambivalent,prescrib
B类：
Physicians,perspectives,adverse,reactions,pediatric,routine,care,survey,Background,Children,adolescents,particular,risk,ADRs,We,investigated,physicians,perceptions,Methods,In,this,exploratory,study,from,April,November,invited,treating,patients,across,Germany,complete,online,questionnaire,consisting,mainly,closed,questions,Results,Completion,rate,was,Of,all,participants,stated,they,were,not,able,how,their,experienced,during,therapy,remaining,estimated,that,median,Q25,affected,by,Regarding,counseling,ask,regularly,extent,which,parents,want,informed,total,avoid,concerning,commonly,used,approved,therapies,whereas,did,so,off,label,Altogether,rather,medicines,hope,better,effectiveness,said,cautious,about,doing,owing,yet,unknown,respondents,authorities,Concerning,black,triangle,symbol,European,pharmacovigilance,knew,reported,suspected,drugs,Conclusions,influenced,struggled,impact,aware,specific,measures
AB值：
0.515545
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
