典型文献
Non-glomerular Tip Lesion Focal Segmental Glomerulosclerosis as a Negative Predictor in Idiopathic Membranous Nephropathy
文献摘要：
Objective:To assess the significance of focal segmental glomerulosclerosis(FSGS)variants on clinicopathological characteristics and short-term outcomes in idiopathic membranous nephropathy(IMN)patients.Methods:The clinicopathological data of 146 IMN patients diagnosed between December 2016 and March 2019 in our center were collected and analyzed.These patients were divided into the pure IMN group,IMN with glomerular tip lesion(GTL)group,and IMN with non-GTL FSGS group.Results:The IMN with non-GTL FSGS and IMN with GTL groups both had higher proportions of patients with hypertension,lower serum albumin,and severe proteinuria,while the IMN with non-GTL FSGS group additionally showed higher blood pressure and serum cholesterol,and lower serum IgG than the IMN group(all P＜0.05).As for pathology,the IMN with non-GTL FSGS group had higher proportions of patients with acute tubular injury and moderate to severe chronic injuries than the IMN group(all P＜0.05).In the IMN,IMN with GTL,and IMN with non-GTL FSGS groups,the overall one-year remission rates were 81.6％,76％,and 58.8％,respectively.Furthermore,the IMN with non-GTL FSGS group showed the lowest cumulative incidence to reach remission within one year.Multivariate Cox logistic analysis demonstrated that higher level of serum anti-M-type phospholipase A2 receptor antibody and the existence of non-GTL FSGS lesion were independent predictors for no remission in IMN patients.Conclusion:The non-GTL FSGS lesion was a novel negative predictor in IMN and should be taken into account in the management of IMN.
文献关键词：
中图分类号：
作者姓名：
Hui WANG;Cheng WAN;Man JIANG;Chun ZHANG
作者机构：
Department of Nephrology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Renal Division,University of Freiburg Medical Center,Freiburg 79106,Germany
文献出处：
引用格式：
[1]Hui WANG;Cheng WAN;Man JIANG;Chun ZHANG-.Non-glomerular Tip Lesion Focal Segmental Glomerulosclerosis as a Negative Predictor in Idiopathic Membranous Nephropathy)[J].当代医学科学(英文),2022(05):1007-1014
A类：
Glomerulosclerosis
B类：
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AB值：
0.474891
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